| 李季 邹波峰 王远鹤 阮有民 刘恒.川穹嗪对胸部肿瘤患者TGF-beta1水平的影响及放疗性肺损伤的预防作用[J].现代生物医学进展英文版,2016,16(8):1494-1497. |
| 川穹嗪对胸部肿瘤患者TGF-beta1水平的影响及放疗性肺损伤的预防作用 |
| Study on the Effect of Ligustrazine Injection on the Level of TGF- in Patientswith Lung Injury Beta 1 Radiation |
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| DOI： |
| 中文关键词: 放射性肺损伤 转化生长因子-beta1 川芎嗪注射液 预防 |
| 英文关键词: Radiation induced lung injury Transforming growth factor beta 1 Ligustrazine injection Prevention |
| 基金项目:辽宁省科委自然基金项目(20032111) |
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| 中文摘要: |
| 目的：探讨川穹嗪注射液对血浆TGF-beta1 水平的影响及对放射性肺损伤的预防作用。方法：随机选取120 例胸部肿瘤放疗患
者分为观察组与对照组，所有研究对象给予三维适形放射治疗，观察组在放疗期间川芎嗪注射液每日静脉滴注1 次；检测两组放
疗前后血浆TGF-beta1含量变化、放射性肺损伤及肺功能情况。结果：放疗后两组血浆TGF-beta1 均上升，观察组在放疗结束时、放疗
结束后3 月、6 月的血浆TGF-beta1 含量明显低于对照组(P<0.05) (19.12± 5.23) vs(26.69± 5.38)ng/mL、(5.62± 3.48)vs(9.64± 7.82)
ng/mL、(3.28± 1.81)vs (7.98± 5.16) ng/mL；观察组放射性肺损伤发生率低于对照组(P<0.05)；观察组放疗后三月肺功能指标用力肺
活量(FVC)、第1 秒用力呼气容积(FEV)、肺总量(TLC)、CO弥散量(DLCO)出现明显下降的例数显著低于对照组(P<0.05)。结论：川
芎嗪注射液可以降低放疗肺损伤患者的血浆TGF-beta1 含量，降低放射性肺炎与放射性肺纤维化的发生率，改善肺功能，无明显不
良反应、安全性好，可起到较好的预防放疗后放射性肺损伤的作用。 |
| 英文摘要: |
| Objective:To investigate the effect of Ligustrazine Injection on plasma TGF- beta 1 level and preventive effect on
radiation-induced lung injury.Methods:120 patients with thoracic tumor radiotherapy were randomly divided into observation group and
control group, 60 cases, 60 cases, all the patients were treated with three-dimensional conformal radiation therapy. The observation group
was treated with ligustrazine injection 1 times daily. The plasma levels of TGF- beta 1 were detected before and after radiotherapy. The
incidence of radiation induced lung injury was observed in the two groups after radiotherapy 3months and 6months.Results:The plasma
levels of TGF- 1 in the two groups were increased, and the levels of TGF- in June and March were significantly lower than those in the
control group (P<0.05) (19.12 ± 5.23) vs (26.69 ± 5.38) ng/mL, (5.62 ± 3.48) vs (9.64 ± 7.82) ng/mL, (3.28 ± 1.81) vs (7.98 ± 5.16)
ng/mL. The incidence of lung injury in the observation group was significantly lower than that in the control group (FVC). The TLC,
DLCO and P<0.05 were significantly lower than those in the control group (P<0.05).Conclusion:ligustrazine injection can reduce the
content of TGF- beta 1 in patients with lung injury, reduce the incidence of radiation pneumonia and pulmonary fibrosis, improve lung
function, no obvious adverse reactions, good safety, can play a good role in preventing radiation-induced lung injury after radiotherapy. |
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