欢迎访问《现代生物医学进展》编辑部！

目的：探讨与传统心脏再同步化治疗（Bi-Ventricular Pacing Cardiac Resynchronization Therapy，Bi-V CRT)相比，左室多部位起搏（Multisite Left Ventricular Pacing，MSLV）CRT 对术后起搏心电图QRS波时限及心肌复极参数的影响。方法：选取具有最新指南推荐植入心脏再同步化起搏或/ 和除颤器（CRT-P/CRT-D）适应症的患者。术中设定左室单部位与右室（1LV+RV）起搏和左室双部位与右室（2LV+RV）起搏。同时采集即时体表12 导联心电图。分析比较2种起搏模式下患者的术后起搏心电图QRS 波时限、QTc 间期、JTc间期及Tp-e 间期。结果：（1）共采集了21 份左室单部位与右室起搏心电图，18 份左室双部位与右室起搏心电图；（2）与1LV+RV 相比，2LV+RV 可进一步缩短术后QRS 时限（△QRS：-5.57± 12.52 ms vs -14.94 ± 14.01 ms，P=0.034）；（3） 1LV+RV与2LV+RV 比较，QTc、JTc 及Tp-e 时限无差异（P>0.05）。结论：与Bi-V CRT 相比，MSLV CRT 可进一步缩短QRS 时限，但不能缩短心肌复极时间。

英文摘要:

Objective:To investigate the effects of multi-site left ventricular pacing (MSLV) cardiac resynchronization therapy （CRT）on pacing electrocardiogram QRS duration and myocardial repolarization parameters compared with traditional biventricular pacing cardiac resynchronization therapy (Bi-V CRT).Methods:Patients who meet the newest guidelines of cardiac resynchronization therapy and/or defibrillator (CRT-P/CRT-D) implantation were enrolled. During operation,we set one-site left ventricular plus right ventricular(1LV + RV) pacing, two-site left ventricular plus right ventricular(2 LV + RV) pacing. Surface 12-lead electrocardiograms are collected and electrocardiogram QRS duration and myocardial repolarization parameters of two pacing modes are analyzed.Results:（1） We have collected 21 electrocardiograms of 1LV + RV and 18 electrocardiograms of 2LV + RV. (2) Compared with the 1LV + RV, 2 LV + RV can further decrease QRS duration（△QRS: -5.57± 12.52 ms vs -14.94 ± 14.01 ms, P=0.034）. (3) QTc, JTc and Tp-ec duration of 2LV + RV is same to 1LV + RV (P>0.05).Conclusion:Compared with the Bi-V CRT, MSLV CRT can further decrease QRS duration, but cannot reduce myocardial repolarization time.

View Full Text View/Add Comment Download reader