| 刘承春 吴芳 张志宏 吴娅 许志强 张猛.脑出血患者脑脊液Abeta水平检测及其临床意义[J].现代生物医学进展英文版,2016,16(8):1472-1474. |
| 脑出血患者脑脊液Abeta水平检测及其临床意义 |
| Abeta Levels in the CSF of Patients with Intracerebral Hemorrhage |
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| DOI： |
| 中文关键词: 脑出血 神经损伤 Abeta |
| 英文关键词: Intracerebral hemorrhage Neuronal degeneration Abeta |
| 基金项目:国家自然科学基金项目（81271411） |
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| 中文摘要: |
| 目的：探讨脑出血患者脑脊液中amylid-beta（Abeta）40 和Abeta42 水平及其与出血量以及血肿周围低密体积相关性。方法：采集
73 例脑出血患者及72 例健康对照的脑脊液标本，采用酶联免疫吸附法（Elisa）检测脑脊液中的Abeta40 和Abeta42 的水平，分析其与
出血量和血肿周围低密度体积的相关性。结果：（1）脑出血患者脑脊液Abeta40 和Abeta42 水平显著高于健康对照组（P<0.01）。（2）脑
出血患者脑脊液Abeta40（r=0.549，P<0.01；r=0.791，P<0.01）和Abeta42（r=0.450，P<0.01；r=0.440，P<0.01）水平与出血量及血肿周围低
密度体积呈正相关。结论：Abeta40 和Abeta42 水平为神经元损害的标志物，本研究提示脑脊液Abeta40 和Abeta42 水平对于判断脑出血严
重程度具有临床参考价值。 |
| 英文摘要: |
| Objective:To investigate the levels of Abeta40 and Abeta42 in the CSF of patents with intracerebral hemorrhage
(ICH) and their correlations with the hemorrhagic volume and the volume of perihematomal hypodensity.Methods:Enzyme-linked
immuno sorbent assay (Elisa) was used to investigate the levels of Abeta40 and Abeta42 in CSF of 73 ICH patients and 72 normal
controls (NC).Results:The levels of Abeta40 and Abeta42 in CSF were significantly increased in ICH patients when compared with NC
group (P<0.01). The levels of Abeta40 in CSF (r=0.549, P<0.01; r=0.791, P<0.01) and Abeta42 (r=0.450, P<0.01; r=0.440, P<0.01) were
positively correlated with the hemorrhagic volume and the volume of perihematomal hypodensity.Conclusion:As the levels of Abeta
proteins in CSF reflect the status of neuronal degeneration, the increased levels of Abeta in CSF indicate that ICH patients experience
significant neuronal degeneration. In this regard, the Abeta levels in CSF might be valuable for estimation of the disease severity of ICH
patients. |
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