| 李亚琴 孔宪明△ 卢燕鸣 薛海燕 曹兰芳.5 岁以下儿童ORMDL3基因表达与哮喘预测指数相关性分析[J].现代生物医学进展英文版,2016,16(8):1462-1466. |
| 5 岁以下儿童ORMDL3基因表达与哮喘预测指数相关性分析 |
| Analysis for Correlations of the Expressions of Orosomucoid 1-like 3 and theAsthma Predictive Index in Children under 5 Years Old |
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| DOI： |
| 中文关键词: 基因 哮喘预测指数 严格标准 相关性 |
| 英文关键词: Orosomucoid 1-like 3 Asthma predictive index Strict conventions Correlation |
| 基金项目:上海市科学技术委员会科研计划项目医学重大课题（10DZ1951000）；上海市卫生适宜技术医学重大课题（2010Y140） |
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| 中文摘要: |
| 目的：为了探究（orosomucoid 1-like 3）基因表达量与哮喘预测指数（Asthma predictive index，API）、性别、年龄、遗
传和环境等因素之间的相关性。方法：从2013 年4 月-2014 年8 月，我们收集了115 位数据有效的5 岁以下儿童的资料，并依据
API严格标准对其进行分类：API+(过去一年内喘息次数≥ 4)、API-（过去一年内喘息次数1-3 次）和API0（无喘息）组，统计三组之
间的基本资料，并检测基因表达量与API、性别、年龄、家族史、喘息次数、和鼻炎之间的相关性。结果：API+组内男女性
别比例显著高于其他组， 基因表达量在API0 内的表达量显著高于API+ 和API- 组内表达量（P = 0.044），并且
基因表达量与API指数之间存在一定的相关性（相关系数：- 0.232，P = 0.020），但是基因表达量与性别、年
龄、家族史、喘息次数、和鼻炎之间无统计学相关性（P>0.05）。结论： 基因表达量与API指数之间存在微弱的负相关性，
API阳性鉴定标准需要进一步的改进。 |
| 英文摘要: |
| Objective:The aim of this study was to investigate the correlation between orosomucoid 1-like 3 ( )
expressions and asthma predictive index (API), gender, ages, genetic and environmental factors.Methods:A total of 115 valid nurslings
under the age of 5 years old were enrolled in this study. All the nurslings were divided into 3 groups according to the strict API
conventions: Group API+, the number of wheezing occurred within the past year was no more than 4 times; Group API-, 1-3 times;
Group API0, no wheezing. We performed descriptive analysis for the baseline data, and performed t-test and pearson correlation for
expression with API, gender, age, history, wheezing number and rhinitis, respectively.Results:The gender ratio (male/female)
in Group API+ was significantly higher than those in other two groups. The expression of gene in Group API0 was
significantly higher than those in Group API+ and Group API-, and that in Group API- was a little higher than that in Group API+. This
demonstrated that the expression level of was negatively correlated with API (Correlation coefficient:-0.232, P = 0.020).
However, no correlations were found between the expressions of with gender, age, family history, asthma number and rhinitis
(p > 0.05).Conclusion:There was a weak negative relationship between the API index and the expression of , thus this API
standard should be furtherly improved. |
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