| 王燕燕 许小红 李彦 赵敏 张忠群.熊去氧胆酸对肝硬化大鼠血清IL-6、MMP-3、TIMP-1 及胃肠Cajal 细胞c-kit 表达的影响[J].现代生物医学进展英文版,2016,16(8):1435-1438. |
| 熊去氧胆酸对肝硬化大鼠血清IL-6、MMP-3、TIMP-1 及胃肠Cajal 细胞c-kit 表达的影响 |
| Effect of Ursodesoxycholic Acid on the IL-6, MMP-3 and TIMP-1 Levels inSerumand c-kit Expression in Cajal Cells of Rats with Liver Cirrhosis |
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| DOI： |
| 中文关键词: 肝硬化 IL-6 MMP-3 TIMP-1 胃肠Cajal细胞 |
| 英文关键词: Liver cirrhosis IL-6 MMP-3 TIMP-1 Cajal cells |
| 基金项目:国家自然科学基金项目（30360098） |
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| 中文摘要: |
| 目的：探讨熊去氧胆酸对肝硬化大鼠血清IL-6、MMP-3、TIMP-1 水平及胃肠Cajal细胞c-kit 表达的影响。方法：选取72 只大
鼠，随机分为四组，每组18 只。空白组给予正常饲养，其余三组均注射CCl4，给予酒精和高蛋白饮食，熊去氧胆酸组大鼠注射熊去
氧胆酸1.5 mg/Kg·d；吗丁啉组给予吗丁啉0.85 mg/Kg·d；模型组仅给予注射生理盐水。治疗结束后，对比各组血清IL-6、MMP-3、
TIMP-1 水平及胃肠Cajal细胞c-kit含量。结果：与空白组比较，模型组大鼠血清IL- 6、MMP-3、TIMP-1 水平均明显升高(P<0.01)，
胃肠Cajal细胞c-kit含量显著降低(P<0.01)。与模型组相比，熊去氧胆酸组与吗丁啉组大鼠血清IL-6、MMP-3、TIMP-1 水平均显著
降低(P<0.01)，小肠推进率增高(P<0.01)，胃肠Cajal 细胞c-kit 含量显著升高(P<0.01)；与吗丁啉组相比，熊去氧胆酸组血清IL- 6、
MMP-3、TIMP-1 水平较低(P<0.01)，小肠推进率、胃肠Cajal细胞c-kit 含量显著升高(P<0.01)。结论：熊去氧胆酸对肝硬化具有较好
疗效，可改善肝纤维化和胃肠功能，这可能与其降低血清IL-6、MMP-3、TIMP-1 水平及提高胃肠Cajal细胞C-kit 含量有关。 |
| 英文摘要: |
| Objective:To investigate the effect of ursodesoxycholic acid on the IL-6, MMP-3, and TIMP-1 in serum and c-kit
expression in Cajal cells of rats with liver cirrhosis.Methods:72 rats were selected and randomly divided into four groups. The blank
group were get normal feeding and others group were treated with CCl4 alcohol and high-protein diet. The ursodesoxycholic acid group
was treated with 1.5 mg/Kg·d ursodesoxycholic acid. The domperidone group was treated with 0.85 mg/Kg·d domperidone. The model
group was treated with physiological saline. Then the serumlevels of MMP-3, TIMP-1 and IL-6 and expression of c-kit in gastrointestinal
Cajal cells of different groups were observed and compared.Results:Compared with the blank group, the serum levels of IL-6, MMP-3,
TIMP-1 were higher (P<0.01), the C-kit expression in gastrointestinal Cajal cells was lower (P<0.01). Compared with the model group,
the serum IL-6, MMP-3, TIMP-1 levels were lower in the ursodesoxycholic acid group and the domperidone group (P<0.01), the
intestinal propulsion rate and the C-kit expression in gastrointestinal Cajal cells were higher(P<0.01).Conclusion:Ursodesoxycholic acid
had good curative effect in the treatment of liver cirrhosis, which could improve the liver fibrosis and gastrointestinal function. |
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