| Type 1 diabetes mellitus (Insulin-Dependent Diabetes Mellitus, IDDM) was mainly due to pancreatic islets beta cells
injury caused by autoimmune response. Currently, clinical treatment of type 1 diabetes, mainly revolving conventional oral hypoglycaemic
agents and insulin replacement therapy, could hardly completely cure the disease but only delayed the progression. Recently, successful
induction of IPCs from various of stem cells brought new hope. The protocols of the IPCs induction were multistage and lasted
froma couple of days to months long according to the different sources of stemcells. The extrinsic factors involved differed frommethod
to method, mainly including epidermal growth factor, basic fibroblast growth factor, activin A, betacellulin, gastrin, nicotinamide, exendin-
4, hepatocyte growth factor, glucose and foetal bovine serum. However, the problem of producing sufficient IPCs that could produce
sufficient insulin for clinical use was not resolved. Therefore, before the clinical application of IPCs, further exploration was necessary
for the choice of stemcells, methods, and extrinsic factors for induction. This article mainly reviewed the research progress of the induction
of IPCs fromstemcells. |
