| 董正华 顾晓龙 黄军 周磊 向定成.小剂量洋地黄对急性心肌梗死PCI术后合并心力衰竭患者心率变异性的影响[J].现代生物医学进展英文版,2016,16(7):1295-1298. |
| 小剂量洋地黄对急性心肌梗死PCI术后合并心力衰竭患者心率变异性的影响 |
| Effect of Low Dose Digitalis on Heart Rate Variability in the Patients ofReperfused Acute Myocardial Infarction with Acute Heart Failure |
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| DOI： |
| 中文关键词: 洋地黄 心率变异性 急性心肌梗死 心力衰竭 经皮冠状动脉介入治疗术 |
| 英文关键词: Digitalis Heart rate variability Acute myocardial infarction Heart failure Percutaneous coronary intervention |
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| 中文摘要: |
| 目的：探讨早期应用小剂量洋地黄类药物对急性心肌梗死（Acute myocardial infarction, AMI）行经皮冠状动脉介入治疗（Percutaneous
coronary intervention, PCI）术后合并心力衰竭患者心率变异性（Heart rate variability, HRV）的影响。方法：入选32 例在发
病24 小时内接受PCI治疗且合并心力衰竭的AMI患者，再灌注后随机分为洋地黄组（西地兰0.2 mg，n=17）和对照组（生理盐水
20 mL，n=15）。在用药前、用药后30 分钟、用药后3 小时、用药后6 小时、用药后12 小时、用药后24 小时进行5 分钟HRV 分析。
结果：①洋地黄组的心率在用药6 小时后显著小于对照组（P<0.05）；②洋地黄组SDNN在用药后3 小时-6 小时显著大于对照组
（P<0.05），两组RMSSD 比较无显著统计学差别（P>0.05）；③洋地黄组LFnorm在用药后3 小时-6 小时显著大于对照组（P<0.05）；
用药3 小时后，洋地黄组HFnorm 显著大于对照组（P<0.05），LF/HF显著小于对照组（P<0.05）。结论：小剂量洋地黄可以显著降低
AMI PCI术后合并心力衰竭患者的心率、逆转迷走神经与交感神经活性的失衡状态，改善HRV。 |
| 英文摘要: |
| Objective:To investigate the effect of digitalis on heart rate variability (HRV) in patients with acute heart failure
following acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI).Methods:A total of 32
consecutive patients with acute heart failure following AMI within 24 hours who underwent PCI were enrolled in this study. The patients
were randomly divided into two groups after reperfusion therapy: digitalis group (Cedilanid 0.2 mg, n=17) and control group (saline 20
mL, n=15). Electrocardiogram signals were recorded before medication, 30 minutes, 3 hours, 6 hours, 12 hours, and 24 hours after
medication, and then 5 minutes of Time-domain and Frequency-domain of HRV parameters were analyzed.Results:The heart rate of the
digitalis group was significantly lower than that of control group from 6h to 24h after medication (P<0.05). SDNN of digitalis group was
significantly higher than that of control group between 3 hours and 6 hours after medication (P<0.05), and there was no statistically
difference of RMSSD between the two groups. LFnormof digitalis group was significantly higher than that of control group from 3 hours
to 6 hours after medication (P<0.05). HFnorm of digitalis group was remarkable higher than that of control group from 3 hours to 24
hours after medication (P<0.05), and the ratio of LF/HF in digitalis group was significantly lower than that of control group (P<0.05).Conclusion:Low dose digitalis reduced heart rate and improved sympatho-vagal imbalance and HRV in the patients with AMI with acute
heart failure who underwent PCI in the early stage. |
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