| 王晶 丁永年 周达 何玲楠 陈源文.AcSDKP对器官产纤维细胞功能的影响[J].现代生物医学进展英文版,2016,16(6):1161-1163. |
| AcSDKP对器官产纤维细胞功能的影响 |
| Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Fibrogenic Cells ofDifferent Organs |
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| DOI： |
| 中文关键词: N-乙酰基- 丝氨酰-天冬氨酰- 赖氨酰- 脯氨酸 四肽 成纤维细胞 |
| 英文关键词: N-Acetyl-Ser-Asp-Lys-Pro Tetrapeptide Fibroblasts |
| 基金项目:国家自然科学基金项目（81170410；81260081）；上海市卫生系统优秀青年人才培养计划项目（XYQ2011010）；
新疆维吾尔自治区高校科研计划重点项目（XJEDU2012I001） |
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| 中文摘要: |
| N- 乙酰基- 丝氨酰- 天冬氨酰- 赖氨酰- 脯氨酸(N-acetyl-seryl-aspartyl-lysyl-proline, AcSDKP)是广泛存在于哺乳动物体内
的乙酰化小分子四肽，具有广泛的生理功能。近年来，AcSDKP 参与组织器官细胞外基质沉积和纤维化调控的作用与机制越来越
受到国内外学者的重视，已有研究发现其对心、肝、肺、肾等器官纤维化有抑制作用，而这些作用与各器官的产纤维细胞关系密
切。本文就AcSDKP 对心、肝、肺、肾内的产纤维细胞功能影响的研究进展展开综述。 |
| 英文摘要: |
| N-acetyl-seryl-aspartyl-lysyl-proline (N-acetyl-seryl-aspartyl-lysyl-proline, AcSDKP) , an acetylated small molecule
tetrapeptide with broad physiological functions, is widespread in the mammalian. In recent years, the essential role and mechanism of
AcSDKP in regulation of extracellular matrix deposition continues to gain attention in the field of tissue and organ fibrosis. It is found
that AcSDKP has an anti-fibrotic effect in the heart, liver, lung and kidney, etc, and this effect is closely related to the fibrogenic cells in
these tissues or organs, mainly residential fibroblasts. The effects of AcSDKP on these fibrogenic cells will be reviewed in this paper. |
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