| 段小艺 李淼 李宏利 赵周社 郭佑民 朱朝晖 李方.针对tau蛋白PET 示踪剂研究进展[J].现代生物医学进展英文版,2016,16(5):965-969. |
| 针对tau蛋白PET 示踪剂研究进展 |
| Research Development of PET Tracers Aiming at Tau Protein |
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| DOI： |
| 中文关键词: tau 蛋白 正电子示踪剂 PET 成像 阿尔茨海默病 |
| 英文关键词: Tau protein Positron tracer Positron emission computed tomography Alzheimer's disease |
| 基金项目:国家自然科学基金（地区项目）（81160180） |
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| 中文摘要: |
| 阿尔茨海默病(Alzheimer's disease, AD)是一种常见的中枢神经系统退行性疾病，脑内主要病理变化为神经元外由茁-淀粉样
蛋白(Amyloid beta, Abeta)沉积形成的老年斑(Senile Plaques, SP)和神经元内由异常过度磷酸化的微管相关tau 蛋白构成的神经原纤维
缠结(Neurofibrillary Tangles, NFTs)，对这两种病理改变的特异性识别有助于AD早期发现与诊断。既往针对AD的PET 示踪剂多
数作用于Abeta，近年tau 蛋白类PET 示踪剂发展迅速，以[18F]THK-523、[18F]THK-5105 和[18F]THK-5117 为代表的tau 蛋白靶向
PET 示踪剂在AD的诊断与治疗方面显示出巨大的发展潜力与应用前景。 |
| 英文摘要: |
| Alzheimer's disease (AD) is a degenerative disease of central nervous system. Its characteristic pathological change in
brain is the formation of senile plaques (SP) and neurofibrillary tangles (NFTs), which due to A茁deposition and abnormal tau protein aggregation.
The specific recognition of the two proteins should be helpful for early detection and diagnosis of AD. Almost all the existing
PET tracers for AD are PIB and PIB derivatives mainly aiming at Abetaplaque. In recent years, tau protein-based, such as [18F]THK-523,
[18F]THK-5105 and [18F]THK-5117, develop rapidly and show huge developing potential and applicant prospect in diagnosis and therapy
of AD. |
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