| Objective:To observe the effect of Dexmedetomidine(Dex) on hemodynamics and stress reactions of the laparoscopic
hysterectomy patients.Methods:A total of 36 patients, who underwent laparoscopic hysterectomy in Pudong Hospital Affiliated to Fudan
University during Octomber 2012 to Octomber 2014, were selected and randomly divided into experiment group (n=18) and control
group (n=18). The experimental group was intravenously injected with 1 ug/kg Dex until the end of surgery, and the control group, with
normal saline. Mean artery pressure (MAP), heartrate(HR), the levels of cortisol (Cor), norepinephrine (NE) and interleukins-6 (IL-6)
were recorded 15 min before giving Dexmedetomidine infusion (T0), 5 min after tracheal intubation (T1), 20 min after skin incision (T2),
immediately after surgery (T3) and 24 h after surgery (T4).Results:At the time of T0, there was no significant difference in the MAP and
HR of the two groups(P>0.05), but the MAP and HR of control group were significantly higher at T1, T2, T3 (P<0.05), the MAP and HR of
experimental group were slightly elevated, there were significant differences between the two groups (P<0.05). The MAP and HR of the
two groups resumed to normal levels at the time of T4. There was no significant difference in the Cor, NE and IL-6 of the two groups at
the time of T0. (P>0.05), but the Cor, NE and IL-6 of control group significantly increased at T2, T3, T4 (P<0.05), the Cor, NE and IL-6 of
experimental group were slightly elevated, there were significant differences between the two groups (P<0.05). The other indexes of the
two groups arrived to peak excepting NE.Conclusion:Dex can maintain the hemodynamic stability of surgical patients,and reduce the
patients' stress response. |
