| 魏萌 谢庆云 王涛 程悦 朱军 龙洁.甲氨蝶呤联合羟基氯喹对类风湿关节炎合并糖尿病患者糖化血红蛋白水平的影响[J].现代生物医学进展英文版,2016,16(4):723-726. |
| 甲氨蝶呤联合羟基氯喹对类风湿关节炎合并糖尿病患者糖化血红蛋白水平的影响 |
| Effect of Methotrexate Combination Hydroxychloroquine Treatmenton Glycosylated Hemoglobin Level in Rheumatoid Arthritis Patientswith Diabetes |
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| DOI： |
| 中文关键词: 类风湿关节炎 糖尿病 羟基氯喹 甲氨蝶呤 糖化血红蛋白 回顾性研究 |
| 英文关键词: Rheumatoid arthritis Diabetes mellitus Hydroxychloroquine Methotrexate Glycosylated hemoglobin Retrospective
study |
| 基金项目: |
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| 中文摘要: |
| 目的：观察类风湿关节炎（rheumatoid arthritis，RA）合并糖尿病（diabetes mellitus, DM）患者使用甲氨蝶呤（methotrexate,
MTX）联合羟基氯喹（hydroxychloroquine, HCQ）治疗前后糖化血红蛋白（glycosylated hemoglobin, HbA1C）水平的变化。方法：通过
回顾性分析，选取联合使用MTX+HCQ或单独使用MTX治疗的RA合并DM 患者，且在治疗前及开始治疗12 个月内分别至少
有1 次HbA1C 值，记录其年龄、性别、诊断、体重指数、使用糖皮质激素情况。计算用药前到用药后12 个月内HbA1C 最低值的变
化。结果：40 例使用HCQ+MTX 和45 例使用MTX患者符合入选标准。两组间年龄、性别、体重指数、用药前HbA1C水平相似，
MTX+HCQ 组糖皮质激素使用比例（40.00%）比HCQ 组更多(26.67%) (P= 0.25)。MTX+HCQ组治疗后HbA1C 有明显下降
（0.42%，P=0.00），且MTX+HCQ 组HbA1C 降低幅度高于MTX组(0.42%，0.12%，P = 0.02)。结论：与单独使用MTX 相比，RA 合
并DM患者联合使用HCQ+MTX 可明显降低HbA1C 水平。 |
| 英文摘要: |
| Objective:To examine the effect of methotrexate (MTX) combination hydroxychloroquine (HCQ) treatment on
glycosylated hemoglobin (HbA1c) level in rheumatoid arthritis (RA) patients with diabetes mellitus (DM).Methods:We identified RA
patients beginning treatment with either MTX+HCQ or MTX using retrospective analysis. The patients had a diagnosis of DM and at
least one HbA1c measurement both before and within 12 months after initiation of treatment. We recorded age, sex, body mass index
(BMI), disease diagnosis, DM medication, cumulative steroid use, HbA1c value before and after drug treatment.Results:We identified
40 patients taking HCQ+MTX and 45 patients taking MTX who met the inclusion criteria. There were no significant differences of age,
sex, BMI and mean pretreatment HbA1c levels between two groups. More patients used glucocorticoid in MTX+HCQ group (40.00%)
than in MTX group (26.67%) (P=0.25). The HbA1c value was significantly reduced after taking HCQ+MTX treatment. The change of
HbA1c from pretreatment values to the lowest posttreatment values was 0.42% in HCQ+MTX group, compared with 0.12% in MTX
group.Conclusion:HCQ+MTX treatment was associated with a significantly greater reduction in HbA1c as compared with MTX
treatment in RA patients with DM. |
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