| 李辉 王育文 黄鹤 张凤民 孙殿军.Gelsolin蛋白在类风湿性关节炎和系统性红斑狼疮的临床诊断及疾病活动度评价中的意义[J].现代生物医学进展英文版,2016,16(4):696-700. |
| Gelsolin蛋白在类风湿性关节炎和系统性红斑狼疮的临床诊断及疾病活动度评价中的意义 |
| The Value of Plasma Gelsolin Levels in Diagnosis and Disease ActivityEvaluation in Patients with Systemic Lupus Erythematosus and RheumatoidArthritis |
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| DOI： |
| 中文关键词: gelsolin 蛋白 类风湿关节炎 系统性红斑狼疮 疾病活动度 |
| 英文关键词: Gelsolin Rheumatoid arthritis Systemic lupus erythematosus Disease activity |
| 基金项目:哈尔滨市科技局项目（2012RFQXS046） |
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| 中文摘要: |
| 目的：分析gelsolin 蛋白对类风湿性关节炎（rheumatoid arthritis, RA）和系统性红斑狼疮（systemic lupus erythematosus，SLE）
的临床诊断及疾病活动度评价的意义。方法：采集RA 30 名和SLE 47 名及健康人群50 名的临床资料及血清标本，定量Western
Blot法检测血清gelsolin 水平。分析gelsolin 蛋白与RA和SLE 患者临床表现及疾病活动度的相关性。结果：RA、SLE 和正常对照
组之间性别、年龄、血红蛋白、血小板、血红细胞、血白细胞之间没有显著差异；RA患者出现CRP、转氨酶、RF、CCP 异常的阳性率
明显高于SLE患者（P<0.05）；而SLE 患者出现白蛋白、尿蛋白、尿红细胞、尿素氮、ANA、肌酐异常增高的几率高于RA 患者（P<0.
05）。gelsolin蛋白在SLE 和RA血清中的含量均显著低于正常人（P<0.05），且RA患者含量更低（P<0.05）。gelsolin 蛋白滴度与
RA的疾病活动度无明显相关性（r=0.089，P=0.652），而与SLE 的疾病活动度呈显著负相关（r=0.646, P<0.05）。gelsolin 蛋白正常组
RA患者的转氨酶升高、CRP、RF、CCP阳性率均显著高于SLE 患者（P<0.05）。gelsolin 蛋白降低组SLE 患者的白蛋白、尿蛋白、尿
红细胞、尿素氮、ANA、肌酐阳性率显著高于RA患者（P<0.05）。结论：gelsolin 蛋白滴度检测可作为RA 和SLE 临床辅助诊断手
段，其滴度变化可作为SLE 疾病活动度进展的预判指标。 |
| 英文摘要: |
| Objective:To analyse the value of plasma gelsolin levels in patients with systemic lupus erythematosus and
rheumatoid arthritis in diagnosis and disease activity evaluation.Methods:Plasma samples and clinical data were collected from 47 SLE
patients, 30 RA patients and 50 age- and gender-matched healthy individuals. Semiquantitative western blotting was used for measuring
plasma gelsolin levels.Results:The plasma gelsolin levels in patients with SLE and RA were significantly decreased compared with
healthy controls (145.3± 40.4 versus 182.7± 38.3 mg/L and 100.8± 36 versus 182.7± 38.3 mg/L, P<0.001), and plasma gelsolin levels
were especially lower in RA than in SLE patients (100.8 ± 36 versus 145.3± 40.4 mg/L, P<0.001). An analysis of the clinical data
showed a significant negative correlation between plasma gelsolin levels and SLE Disease Activity Index (SLEDAI) scores (r=0.659,
P<0.001) but no correlation between plasma gelsolin levels and RA disease index scores (DAS28, r=0.076, P=0.569).Conclusion:This
study found significantly lower plasma gelsolin levels in patients with SLE and RA compared with healthy controls and documented a
significant negative correlation between plasma gelsolin levels and SLEDAI, which suggested the potential clinical application of plasma
gelsolin in SLE diagnosis and disease activity evaluation. |
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