| 王波 付琳 王莹惠 杜洪伟 栾颖.白介素-18 基因多态性与黑龙江省汉族人群心房颤动相关性[J].现代生物医学进展英文版,2016,16(4):629-634. |
| 白介素-18 基因多态性与黑龙江省汉族人群心房颤动相关性 |
| Correlation of the Gene Polymorphisms of Interleukin -18 with Risk of AtrialFibrillation in Han Population of Heilongjiang Province |
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| DOI： |
| 中文关键词: 心房颤动 白介素-18 单核苷酸多态性 单体型 等位基因 基因型 |
| 英文关键词: Atrial fibrillation Interleukin-18 Single nucleotide polymorphisms Haplotypes |
| 基金项目:黑龙江省教育厅科学技术研究项目（11531079） |
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| 中文摘要: |
| 目的：探讨白介素-18(IL-18)基因启动子区-137G/C(rs187238)位点和-607A/C(rs1946518)位点的等位基因、基因型、单体型与
黑龙江省汉族人群心房颤动发病风险的相关性。方法：选取56 例心房颤动患者和26 例对照者，心房颤动患者按持续时间分为阵
发房颤组和持续房颤组。采用聚合酶链式反应(PCR)和直接测序法(DS)对所选2 个SNPs位点的基因型进行检测。结果：①黑龙江
省地区汉族人群中IL-18 基因启动子区-607A/C 位点存在AA、AC、GG三种基因型，-137C/G 位点存在CC、GC、GG三种基因型。
②各心房颤动患者组与对照组间IL-18 基因启动子区-137G/C(rs187238)位点和-607A/C(rs1946518)位点的基因型和等位基因频
率比较均无显著性差异(P>0.05)。③IL-18 基因启动子区-137G/C(rs187238)位点和-607 A/C (rs1946518)位点有CA、CC、GA、GC
四种单倍体型，各组单倍体型分布频率比较均无统计学差异(P>0.05。④IL-18 基因启动子区-137G/C(rs187238)位点和-607 A/C
(rs1946518)位点的基因型和等位基因频率与AF患者的发病年龄均无统计学相关性(P>0.05)。结论：IL-18 基因启动子区-607A/C
(rs1946518)位点和-137G/C(rs187238)位点不是黑龙江省汉族人群心房颤动的易感基因，可能与其心房颤动的发病风险无关。 |
| 英文摘要: |
| Objective:To investigate the association between rs187238 and rs1946518 loci of Interleukin -18 gene promoter
region with risk of atrial fibrillation (AF) in Han population of Heilongjiang province.Methods:56 patients with atrial fibrillation and 26
normal controls were included in this study. AF group was divided by the duration of paroxysmal group and persistent group. We
determined the genotypes of two SNPs using polymerase chain reaction-direct sequencing.Results:① AA, AC, CC genotypes were
existed in the rs1946518 site of IL-18 gene promoter, while CC, GC, GG genotypes were exsisted in the rs187238 site of IL-18 gene
promoter in Heilongjiang Province Han population. ② No significant difference was found in the genotypes and allele frequencies of
rs187238 loci and rs1946518 loci in IL-18 gene promoter among various AF patients and control group (P> 0.05). ③IL-18 gene promoter
region - 137G/C (rs187238) loci and - 607A/C (rs1946518) loci had CA, CC, GA, GC haploid type, distribution requency comparison
between groups haplotype showed no statistical difference (P>0.05). ④There was no relevance between the genotype, allele frequencies
of this two SNPs and age of AF in various AF group and the control group (P> 0.05).Conclusion:rs187238 and rs1946518 loci in
interleukin -18 gene promoter region were not the susceptible gene of the patients with AF in Han population of Heilongjiang province,
which might had no correlation with the risk of AF. |
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