| 谢瑜 罗惠民 余亚玲 周晓萍 陈飞.非透析慢性肾脏病患者心脏功能生物标记物的临床价值比较[J].现代生物医学进展英文版,2016,16(3):507-510. |
| 非透析慢性肾脏病患者心脏功能生物标记物的临床价值比较 |
| Comparison of the Clinical Significances of Cardiac Function Biomarkersin Patients with Non-dialysis Chronic Kidney Disease |
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| DOI： |
| 中文关键词: 慢性肾脏病 心脏功能 生物标记物 |
| 英文关键词: Chronic kidney disease Cardiac function Biomarkers |
| 基金项目:云南省科技厅应用基础研究计划项目（2011FZ281） |
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| 中文摘要: |
| 目的：比较非透析慢性肾脏病患者心脏功能生物标记物的临床应用价值。方法：选取122 例非透析且无急性冠脉综合征
(ACS)的慢性肾脏病患者(CKD)，将其分为CKD1-2 期组、CKD3-4 期组和CKD5 期组，同时选择同期确诊急性冠脉综合征的慢性
肾脏病患者20 例作为对照组，观察并比较各组患者室间隔厚度(IVST)、左室后壁厚度(LVPWT)，检测血液中血肌酐(Scr)、尿素氮
(BUN)、心型脂肪酸结合蛋白(HFABP)、心肌钙蛋白(cTnI)以及肌酸激酶同功酶(CK-MB)。结果：非ACS的CKD患者HFABP、cTnI、
CK-MB 水平均呈不同程度增高，且各CKD组中这三个指标的阳性率存在显著差异，其中HFABP 阳性率最高(P<0.05)。cTnI 与
eGFR、Scr 及年龄无显著相关性(P>0.05)，但与IVST、LVPWT 呈显著正相关(P<0.05)；CK-MB 与eGFR、Scr、年龄、IVST、LVPWT
均无相关性(P>0.05)；HFABP 与eGFR 呈负相关(P<0.05)，与Scr 和BUN 正相关(P<0.05)，与年龄、IVST、LVPWT 无相关性(P>0.
05)。结论：在非ACS的CKD患者中，HFABP 可能不是一个可靠的反映心脏功能的生物标记物，cTnI 及CK-MB 对于CKD患者
而言是较为可靠的心脏标记物。 |
| 英文摘要: |
| Objective:To compare the cardiac biomarkers in chronic kidney disease patients without dialysis.Methods:122
non-dialysis CKD patients without ACS were included in the study, and they were divided into the CKD1-2 group, the CKD3-4 group
and the CKD5 group based on the value of eGFR. Choose 20 cases ACS patients with chronic kidney disease in the same period as control
group, All the patients were examined by echocardiographic examination, recording interventricular septal thickness (IVST) and left
ventricular posterior wall thickness (LVPWT); Blood samples were taken for measurement of blood urea nitrogen (BUN), Serum creatinine
(Scr), heart-type fatty acid binding protein (HFABP), cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB).Results:The
HFABP, cTnI and CK - MB were increased to some extent in the 122 patients, and there were statistically significant differences about
the positive rates of HFABP, cTnI and CK - MB in the three groups, and the HFABP was the highest (P<0.05). There was no correlation
of cTnI with the eGFR, Scr and age (P>0.05); There was positively correlation of cTnI with IVST and LVPWT (P<0.05); There was no
correlation of CK-MB with eGFR, Scr, age, IVST and LVPWT (P>0.05); There was negatively correlation of HFABP with eGFR, and
positively correlation with Scr and BUN(P<0.05); There was no correlation of HFABP with age, IVST and LVPWT (P>0.05).Conclusion:HFABP is not an ideal myocardial marker in CKD patients without ACS; cTnI and CK-MB could be a reliable myocardial marker for
chronic kidney disease. |
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