| 马俊 左传 马勇胜 潘洪志 杨卫良.氧化应激反应与膝关节骨性关节炎的相关性探究[J].现代生物医学进展英文版,2016,16(3):500-503. |
| 氧化应激反应与膝关节骨性关节炎的相关性探究 |
| A Study on the Relationship between Oxidative Stress Reaction andOsteoarthritis of Knee |
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| DOI： |
| 中文关键词: 氧化应激反应 膝关节骨性关节炎 过氧化损伤 |
| 英文关键词: Oxidative stress Knee osteoarthritis Peroxidation damage |
| 基金项目: |
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| 中文摘要: |
| 目的：了解膝关节骨性关节炎患者机体的氧化应激状态，探讨氧化应激反应与膝关节骨性关节炎发生、发展的关系。方法：
收集膝关节骨性关节炎患者及健康人群的血清，采用分光光度法测定和比较其SOD、GSH-Px、MDA水平。结果：与健康对照人群
相比，膝关节骨性关节炎患者体内SOD、GSH-Px 酶类抗氧化剂活力显著增强(P＜0.05)；MDA脂质过氧化损伤产物明显降低(P＜
0.05)。结论：膝关节骨性关节炎患者体内氧化还原状态发生了改变，可能处于抗氧化应激的慢性代偿状态；氧化应激反应参与了
骨性关节炎的发生、发展过程。 |
| 英文摘要: |
| Objective:To detect the oxidative stress status in osteoarthritis of knee and investigate the relationship between oxidative
stress and osteoarthritis of knee.Methods:Collect serumof patients with osteoarthritis of knee and health control to detect concentrations
of SOD,GSH-Px and MDA.Results:The study found that SOD, GSH in patients with osteoarthritis of knee enhance the activity of
antioxidant enzymes compared with normal control groups(P＜0.05); Lipid peroxidation products MDA decreased(P＜0.05).Conclusion:The state of oxidative stress in patients with osteoarthritis had changed and it might stayed at a compensatory stage. Oxidative stress was
involved in the process of the occurrence and development of Osteoarthritis of knee. |
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