| 龚玉竹 庞学利 杨松柏 沈建 周杰.淋巴结转移阴性的胃癌患者临床病理特征及生存探讨[J].现代生物医学进展英文版,2016,16(3):466-469. |
| 淋巴结转移阴性的胃癌患者临床病理特征及生存探讨 |
| The Clinicopathological Features and Prognostic Factors of Patients withNode-negative Gastric Cancer |
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| DOI： |
| 中文关键词: 胃癌 淋巴结转移 病理特征 临床预后 |
| 英文关键词: Gastric cancer Lymph node metastasis Pathological features Clinical outcome |
| 基金项目:国家自然科学基金项目（30972894） |
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| 中文摘要: |
| 目的：探讨淋巴结转移阴性胃癌患者的临床病理特征以及预后影响因素。方法：收集2000 年1 月至2009 年1 月我院收治
的胃癌患者325 例，其中经病理检查显示淋巴结转移阴性的105例患者作为阴性组(LN- 组)，另229 例阳性患者作为阳性组(LN+
组)，比较两组的临床病理特征及临床预后。结果：LN- 组的肿瘤直径、浸润深度及术后化疗与LN+ 组比较差异显著(P<0.05)；LN-
组的5 年生存率为76.2%，显著高于LN+ 组的43.2%(P<0.05)。未透浆膜的LN-患者3 年、5 年生存率显著高于浸透浆膜者，术后
化疗的LN- 患者5 年生存率显著高于未化疗者(P<0.05)，肿瘤直径<5 cm 的LN- 患者3、5 年生存率显著高于≥ 5 cm者(P<0.05)。
单因素分析显示浸润深度、肿瘤大小及术后化疗与LN- 胃癌患者的预后具有密切关系(P<0.05)。COX多因素分析显示浸润深度
是影响LN- 胃癌患者临床预后的独立因素(P<0.05)。结论：淋巴结转移阴性胃癌患者的病灶多位于中下部，男性多于女性，发病年
龄多在60 岁以内，肿瘤直径多不超过5 cm，浸润深度多未浸透浆膜，临床预后优于淋巴结转移阳性胃癌患者，浸润深度是影响淋
巴结转移阴性胃癌患者临床预后的独立因素。 |
| 英文摘要: |
| Objective:To investigate the clinicopathological features and prognostic factors in patients with node-negative gastric
cancer.Methods:325 patients with gastric cancer in our hospital between January 2000 and January 2009 were collected, 105 cases with
node-negative gastric cancer revealed by pathological examination as the negative group (LN-group), and the 229 cases of positive patients
as the positive group (LN+group), the clinicopathological features and clinical outcomes of the two groups were compared.Results:The differences of tumor diameter, invasive depth and postoperative chemotherapy between LN-group and LN+ group were significant (P
<0.05); the 5-year survival rate of LN-group was 76.2%, significantly higher than the 43.2% of LN+ group (P<0.05); The 3 and 5-year
survival rates of LN-patients without infiltrating serosa were significantly higher than those of patients with infiltrating serosa. The 5-year
survival rate of LN-patients with postoperative chemotherapy was significantly higher than patients without postoperative chemotherapy
(P<0.05). The 3 and 5-year survival rates of LN-patients whose tumor diameter was less than 5 cm were significantly higher than those of
patients whose tumor diameter was higher than 5 cm (P<0.05). Single factor analysis showed that the infiltrating depth, tumor size and
postoperative chemotherapy were closely related to the prognosis of LN - patients with gastric cancer (P<0.05). Besides, the infiltrating
depth was the independent factor for the prognosis of LN \- patients with gastric cancer (P<0.05).Conclusion:The lesions of lymph node
metastasis of gastric cancer patients are mostly located in the middle -lower part and appear more in men and those elderly whose age is
within 60 years old. Most tumor sizes are less than 5cm and LN-patients without infiltrating serosa are more common. Besides, the clinical
prognosis in LN-patients is better than that in LN+ patients. The infiltrating depth is the independent factor for the prognosis of LNpatients
with gastric cancer. |
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