| Objective:To explore the influence of simvastatin plus low molecular heparin on D-dimer, N-terminal brain natriuretic
peptide precursor(NT-proBNP), left ventricular ejection fraction(LVEF), left ventricular end-diastolic diameter, serum c-reactive protein
(CRP), plasma fibrinogen (FB), serumtotal cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in patients with chronic heart
failure (CHF).Methods:A total of 80 patients with CHF, who were treated in Dalian Center Hospital fromApril 2010 to July 2014 ,were
selected and randomly divided into treatment group (n=40) and control group (n=40). The two groups were all treated with conventional
therapy, based on which, the treatment group was added simvastatin plus low molecular heparin, the course of treatment was two months.
The levels of D-dimer, NT-proBNP, LVEF, left ventricular end-diastolic diameter, CRP, FB, TC and LDL-C in the two groups before and
after treatment were compared.Results:Compared with before treatment, the levels of D-dimer, NT-proBNP, LVEF, left ventricular
end-diastolic diameter, CRP, FB, TC and LDL-C in the control group after treatment were not obviously improved, while the above
indexes in the treatment group were improved significantly, the differences were statistically significant(P<0.05).Conclusion:Simvastatin
plus low molecular heparin can effectively improve the relevant indexe of patients with CHF, which plays an important role in the clinical
treatment and is worthy of clinical application. |
