| 付婷 刘坤 张维璐 徐锐 高洁 吉兆华 闫永平.miR-375 在HBV相关性肝细胞癌肿瘤组织与癌旁组织中的表达[J].现代生物医学进展英文版,2016,16(2):271-274. |
| miR-375 在HBV相关性肝细胞癌肿瘤组织与癌旁组织中的表达 |
| MiR-375 Expression in Tumor and Adjacent Normal Tissues of Patient with Hepatitis B Virus-associated Hepatocellular Carcinoma |
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| DOI： |
| 中文关键词: HBV miR-375 肝细胞癌 |
| 英文关键词: Hepatitis B virus miR-375 HCC |
| 基金项目:国家自然科学基金青年项目(81302474，8
1473026，81472988)；兰州军区面上项目（CLZ14JB22）；
国家“十一五”重大传染病防治科技重大专项(2012ZX10004907) |
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| 中文摘要: |
| 目的：比较HBV相关性肝细胞癌患者的肝癌组织与癌旁组织中miR-375 的表达。方法：以西京医院进行肝癌切除术治疗的
HBsAg阳性的25 例患者为研究对象，收集肝癌组织、癌旁组织及术前外周血标本，并采集相关临床信息。采用反转录和实时荧光
定量PCR 的方法检测组织中miR-375 的表达水平。结果：本研究共收集的25 例肝癌患者HBsAg 均为阳性，在肝癌组织中
miR-375 的表达水平为2.51× 10-3± 3.61× 10-3，显著低于在癌旁组织中的表达水平(15.23× 10-3± 20.85× 10-3；t=3.12，P＜0.05）。结
论：miR-375 在HBV相关性肝细胞癌肝癌组织中表达显著下调。 |
| 英文摘要: |
| Objective:To investigate the miR-375 expression profiles in hepatocellular carcinoma (HCC) tissues and adjacent
non-tumor tissues.Methods:Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to examine the expression of
miR-375 in 25 HCC from patients who were diagnosed and operated, in comparion with the corresponding adjacent non-tumor tissues.
Based on the medical records, the relevant information was extracted.Results:There were 25 HCC patients in the study. HBsAg of all
patients were positive. The expression of miR-375 in HCC tissues was 2.51× 10-3± 3.61× 10-3, the expression of miR-375 in adjacent
non-tumor tissues was 15.23× 10-3± 20.85× 10-3. The expression of miR-375 in HCC tissues significantly lower than that in adjacent
non-tumor tissues(P＜0.05).Conclusion:miR-375 expression was significantly decreased in tumor tissues of HCC patients. |
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