| 索庆芳 王筠 雷洪涛 王冰 彭明华.Exosome 介导的细胞通讯在中枢神经系统疾病中的研究进展[J].现代生物医学进展英文版,2016,16(1):192-196. |
| Exosome 介导的细胞通讯在中枢神经系统疾病中的研究进展 |
| Research Progress of Exosomes-mediated Cell-cell Communications inCentral Nervous SystemDisease |
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| DOI： |
| 中文关键词: 胞外体 细胞通讯 中枢神经系统 |
| 英文关键词: Exosomes Cell communication Central nervous system |
| 基金项目:国家自然科学基金项目（81473449；81102679） |
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| 中文摘要: |
| Exosome（胞外体）是一种可由多种细胞分泌的纳米级膜性小泡，直径为40～100 nm，其中含有细胞特异性的信号分子、蛋白
质、mRNA 和miRNA。这些成分因为有脂质膜的保护而具有充分的生物学活性，可以在细胞与细胞之间进行信息传递，从而有效
发挥对受体细胞的调节作用。本文综述了近几年关于exosomes的研究成果，从exosome 的基本特征、生物学功能、exosomes介导
的细胞通讯在中枢神经系统疾病发病机制及治疗潜能四个方面，对exosomes的研究现状作一介绍，旨在探讨exosomes在细胞通
讯研究中所面临的问题，为以exosomes作为调节靶点治疗中枢神经系统疾病提供理论参考。 |
| 英文摘要: |
| Exosomes (extracellular) are kinds of nano-membrane vesicles secreted by many types of cells, with the diameter of
40 ~ 100 nm, and some -cell-specific molecules such as proteinsmRNAs and miRNA in the exosomes are surrounded by lipid membrane.
Consequently, the exosomes can transfer signal between cells and play a role in the regulation of recipient cells. We summarized the research
results of exosomes and reviewed the recent progress of exosomes fromthe following four aspects was reviewed in this article: the
basic characteristics of exosomes, the biological function of exosomes, exosomes mediated intercellular communication in the central
nervous system diseases and therapeutic potential. By doing so, we aimed at investigating the problems of exosomes-mediated cell-cell
communications and providing a theoretical reference for exosomes as a regulatory target for the treatment of diseases of the central nervous
system. |
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