| 刘卓 欧阳胜荣 李媛媛 常会波 吴建新.MicroRNA在肿瘤发生发展和诊断中作用的研究进展[J].现代生物医学进展英文版,2016,16(1):163-166. |
| MicroRNA在肿瘤发生发展和诊断中作用的研究进展 |
| Research Advances of the Role of microRNA in Tumorigenesis,Development and Diagnosis |
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| DOI： |
| 中文关键词: microRNA 肿瘤发生 诊断 转移 侵袭 |
| 英文关键词: MicroRNA Tumorigenesis Diagnosis Metastasis Invasion |
| 基金项目:国家重点基础研究发展计划（973）（2013CB530605） |
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| 中文摘要: |
| microRNA 是一类由内源基因编码的长度约为18-25 个核苷酸的非编码单链RNA 分子，可以与靶基因mRNA的3'非编码
区结合，通过降解靶mRNA或(和)抑制靶mRNA 转录后翻译调节靶蛋白的生成，从而发挥其生物学作用。目前，在人体基因组内
发现的microRNA已经超过2500 多个，可能调节着人类1/3 的基因，在维持正常干细胞功能、调控细胞增殖分化及恶性肿瘤发生
过程中均起重要作用。既往的研究表明microRNA 与基因之间相互调控的失衡导致肿瘤的发生。从分子水平上研究microRNA与
肿瘤发生的关系，检测microRNA 与肿瘤相关基因表达情况的改变，分析肿瘤组织和血清中microRNA 表达量与肿瘤分型的关
系，将有利于肿瘤的病因学研究，早期发现和肿瘤治疗及预后判断。本文主要就microRNA 在肿瘤发生发展和诊断中作用的研究
进展进行了综述。 |
| 英文摘要: |
| MicroRNA is a class of endogenous gene encoding a length of about 18-25 nucleotides in single-stranded non-coding
RNA molecules, they can be combined with the 3' non-coding region of the target gene mRNA, degrade the target mRNA or (and) inhibit
the post-translation of target mRNA, thus play a role in the regulation of protein transcription. At present, more than 2500 microRNAs
have been discovered in the human genome, which may regulate 1/3 of human genome. MicroRNAs play an important role in the maintenance
of normal function of stem cells, regulation of cell proliferation, differentiation and occurrence of malignant tumors. Studies have
shown that microRNAs play an important role in the tumorigenesis and development. The breaking balance between the microRNAs and
target genes lead to tumorigenesis. Studies on the relationship between microRNA and cancer at molecular level, detection the changes of
cancer -related microRNA sequences or genes circumstances, analysis of expression levels of microRNA in serum and tumor tissue will
be beneficial to research the cause of tumor, early detection and treatment, and prediction of the prognosis. This article mainly reviews
the role of microRNA in tumorigenesis, development and diagnosis. |
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