| 魏萌 谢庆云 王英 王涛 程悦 朱军.类风湿关节炎患者血脂水平与疾病活动度的相关性研究[J].现代生物医学进展英文版,2016,16(1):103-105. |
| 类风湿关节炎患者血脂水平与疾病活动度的相关性研究 |
| Correlation between Levels of Lipid Profile and Disease Activity inRheumatoid Arthritis |
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| DOI： |
| 中文关键词: 类风湿关节炎 血脂异常 疾病活动度 回顾性研究 |
| 英文关键词: Rheumatoid arthritis Dyslipidaemia Disease activity Retrospective study |
| 基金项目:四川省卫生厅科研项目（130320,130322）；成都军区总医院院管课题（2013YG-B037,2013YG-B096） |
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| 中文摘要: |
| 目的：观察类风湿关节炎（RA）患者血脂的变化，以及血脂水平与疾病活动度之间的相关性。方法：对71 例RA 患者和77 例
正常对照的血脂水平进行回顾性分析，并对RA 患者的血脂水平与其疾病活动度进行相关性分析。结果：RA 患者的血清总胆固
醇（TC）、甘油三酯（TG）水平均高于正常对照组（P< 0.01），高密度脂蛋白（HDL）水平降低（P< 0.01）。DAS28 评分与TC（r=0.49，
P< 0.01）、TG（r=0.38，P< 0.01）和LDL（r=0.55，P< 0.01）呈正相关，与HDL 呈负相关（r=-0.57，P< 0.01），血沉与TC（r=0.26，P=
0.03）、TG（r=0.28，P= 0.02）呈正相关，C 反应蛋白与TC（r=0.65，P< 0.01）、TG（r=0.30，P= 0.01）和LDL（r=0.39，P< 0.01）均呈正相
关。结论：RA患者存在血脂水平异常，且与疾病活动度相关。对血脂进行干预可能改善RA 患者的长期预后。 |
| 英文摘要: |
| Objective:To observe the changes ofserum lipids in rheumatoid arthritis (RA) patients and its correlation with the activity
of this disease.Methods:This study was done on 71 RA patients and 77 normal controls. The lipid profile, ESR, CRP and DAS28
index were recorded by retrospective analysis. The correlation of lipid profile and disease activity was analyzed.Results:Compared with
normal control group, the levels of total cholesterol(TC) and triglyceride (TG) in RA group were higher significantly (P<0.01), HDL level
was lower(P<0.01). DAS28 index was correlated with the levels ofTC(r=0.49, P<0.01), TG(r=0.38, P<0.01), LDL(r=0.55, P<0.01) and
HDL(r=-0.57, P<0.01). ESR was positively correlated with TC(r=0.26, P=0.03) and TG (r=0.28, P=0.02); and CRP was positively correlated
with TC (r=0.65, P<0.01), TG(r=0.30, P=0.01) and LDL (r=0.39, P<0.01).Conclusion:Dyslipidaemia was existed in RA patients
and correlated with disease activity. The management of dyslipidaemia may improve the long-termoutcomes in RApatients. |
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