| 王华 康慧杰 蒋铭佐 许冰 李晓伟 邱兆岩 梁洁.H2-Calponin 在食管鳞癌中的表达及其与食管磷癌预后的关系[J].现代生物医学进展英文版,2016,16(1):84-87. |
| H2-Calponin 在食管鳞癌中的表达及其与食管磷癌预后的关系 |
| The Expression of H2-Calponin in Esophageal Squamous Cancer and ItsCorrelation with the Prognosis of Esophageal Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 食管磷癌 H2-Calponin 表达 预后 |
| 英文关键词: Esophageal squamous cell carcinoma H2 -Calponin Expression Prognosis |
| 基金项目:国家自然科学基金项目(81322037) |
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| 中文摘要: |
| 目的：探讨H2-Calponin 在食管磷癌组织中的表达及其与食管磷癌患者临床病理特征及预后的相关性。方法：利用免疫组织
化学染色技术检测73 例食管磷癌及相应癌旁组织中H2-Calponin 的表达情况，并分析其与食管磷癌患者临床病理参数及预后的
关系。结果：H2-calponin在食管磷癌组织中的阳性表达率为95.8%(70/73)，显著高于癌旁组织(35.8%，24/67)，差异具有统计学意义
(p<0.0001)。H2-calponin 的表达与食管癌患者的性别、年龄、肿瘤大小、浸润深度及淋巴结转移均无显著相关性，但与AJCC分期显
著相关(P<0.05)。H2-calponin 的表达水平影响食管癌患者预后及生存期。结论：H2-Calponin 在食管磷癌组织中呈高表达并可预示
食管磷癌预后不良。 |
| 英文摘要: |
| Objective:To investigate the correlation of H2 -Calponin expression with the clinicopathological characteristics and the
prognosis of esophageal squamous cell carcinoma (ESCC) patients.Methods:Immunohistochemical staining was used to detect the
expression of H2 -Calponin in 72 cases of ESCC tissues and adjacent non-tumor tissues.Results:The expression of H2 -calponin in ESCC
tissues was significantly higher than that of the adjacent non-tumor tissues (P<0.0001). The high expression of H2 -Calponin in ESCC was
significantly related to the AJCC stage of ESCC (P<0.05), but not to the gender, age, tumor size, tumor local invasion depth and
tumor-node-metastasis stage. The prognosis of patients with a higher expression of H2 -calponin was significantly worse than those with
lower expression of H2 -calponin (P<0.05).Conclusion:H2-calponin was highly expressed in ESCC and the high expression of
H2-Calponin might be an independent predictor of the prognosis of ESCC patients. |
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