| 张效林 梁振洋 孙莹 刘滕飞 蔡文芝 闫承慧.白细胞介素23 受体基因rs6682925 多态与冠心病发病的相关关系[J].现代生物医学进展英文版,2016,16(1):63-66. |
| 白细胞介素23 受体基因rs6682925 多态与冠心病发病的相关关系 |
| Association of Interleukin 23 Receptor Rs6682925 Variant with Coronary Artery Disease |
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| DOI： |
| 中文关键词: IL23R 单核苷酸多态性 等位基因 |
| 英文关键词: Interleukin 23 receptor Single nucleotide polymorphism Allele |
| 基金项目:国家自然科学基金青年科学基金项目（81100135） |
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| 中文摘要: |
| 目的：本研究探讨白细胞介素23 受体（Interleukin 23 Receptor,IL23R）基因单核苷酸多态位点（rs1884444 与rs6682925）与中
国北方汉族人群冠心病发病的相关关系。方法：本研究采用病例-对照的设计方法，收集568 名冠心病患者以及45 岁以上、年龄
及性别匹配的524 名正常对照个体为研究对象，采用测序法检测IL23R rs1884444 与rs6682925 单核苷酸多态性基因型，分析
IL23R 基因rs1884444 与rs6682925 单核苷酸多态位点的基因型及等位基因的分布情况。结果：IL23R rs6682925 与rs1884444 单
核苷酸多态位点的基因型频率符合Hardy-Weinberg 定律。IL23R基因rs6682925 单核苷酸多态位点的三种基因型分布频率（CC
型，TC 型和TT 型）在冠心病组为22.9 %，39.6 %和37.5 %，在对照组分别为41.7 %，47.2 %和11.1 %，IL23R基因rs6682925 单核
苷酸多态位点C 等位基因是冠心病发病的一个独立的危险因素(P＜0.05)；IL23R基因rs1884444 单核苷酸位点的基因型和等位
基因的频率在对照组和冠心病组之间不存在统计学差异(P＞0.05)。Logistic回归校正性别、年龄、体重指数、吸烟、高血压、高脂血
症、糖尿病等冠心病的易患因素后，IL23R 基因rs6682925 C等位基因仍是冠心病发病一个独立危险因素。结论：在中国北方汉族
人群中，IL23R基因rs6682925 C等位基因可能是冠心病发病的独立危险因素。 |
| 英文摘要: |
| Objective:To investigate the association between the interleukin 23 Receptor(IL23R) rs6682925variant with coronary
artery disease (CAD) in Northern Han population of China.Methods:The study was conducted in 568 coronary artery disease patients
and 529 control subjects in a case-control study. We used the gene directing sequencing technology to detect the Il23R rs6682925 and
rs1884444 variant.Results:We found that the IL23R rs6682925 and rs1884444 variant frequency conformed well to the Hardy-Weinberg
equilibrium in both case and control subject. IL23R rs6682925（CC, TC and TT）genotype frequency was 22.9 %, 39.6 %and 37.5 %in
CAD group and 41.7 %, 47.2%and 11.1 %in control group. IL23R rs6682925 C allele was a genetic risk factor for coronary artery disease
in Northern Han population of China (P＜0.05). There were no significant differences in the genotype and allele distribution of
IL23R rs1884444 variant between CAD and control subjects (P＞0.05). Logistic regression analysis with adjustments for the other risk
factors showed that the C allele carriers of IL23R rs6682925 variant significantly increased the risk of coronary artery disease compared
with the non-carriers(P＜0.05).Conclusion:IL23R rs6682925 variant may be considered a genetic risk factor for CAD in Northern Han
population of China. |
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