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目的：探究新型表面活性剂分子Pa-Brij78 在药物传递方面的应用。方法：利用Brij78 合成Pa-Brij78，通过薄膜水化法得到 3 mM包载姜黄素的Pa-Brij78 胶束水溶液，并通过共沉淀法用磷酸钙将胶束矿化的流程建立磷酸钙胶束复合纳米颗粒药物传递系统；利用Pa-Brij78 作为稳定剂，与紫杉醇按不同的紫杉醇/ 表面活性剂质量比例溶于氯仿后用氮气吹干，真空干燥2-4 h，薄膜物水化30 min后超声20 min 的流程建立纳米晶体Pa-PNC。运用粒度仪和扫面电子显微镜对两种纳米系统进行表征。结果：磷酸钙胶束复合纳米颗粒粒径小于200 nm，纳米颗粒外貌都是球形且表面粗糙对姜黄素的载药率达17 %，包封率大于90%，构建得到的不同比例的纳米晶体Pa-PNC，其粒径也都小于200 nm，Pa-PNC 纳米晶体是棒状的，且Pa-PNC 的载药率达50 %。结论：本课题组合成的新型表面活性剂分子Pa-Brij78 能够构建得到两种药物传递系统，在药物传递系统方面具有一定的应用潜力。

英文摘要:

Objective:To investigate the application of the new surfactant molecular Pa-Brij78 in the field of drug delivery systems.Methods:The calcium phosphate coated micelle nanoparticles were fabricated as follows: the Pa-Brij78 molecular was synthesized using the Brij78 molecular. The micelle solutions and curcumin loaded micelle solution of Pa-Brij78 were prepared by the thin film hydration method. Then, the calcium phosphate coated micelle nanoparticles were fabricated through the mineralization of the micelle by the co-precipitation method. The Pa-PNC nanocrystals were constructed as follows: paclitaxel (PTX) and Pa-Brij78 (used as stabilizer) were first dissolved in chloroform with different weight ratios of PTX/ surfactant, and then co-precipitated by evaporating the chloroform with nitrogen gas. Residual chloroform remained was removed under a vacuumfor 2-4 h. The lipid film was allowed for hydration for 30 min and the suspensions were sonicated for 20 min. Particle analyzer and SEM were used in the characterizeation of the nano-systems.Results:The particle size of calciumphosphate coated micelle nanoparticles were all less than 200 nm. The loading efficiency of curcumin could reach 17 %, and the encapsulation efficiency were above 90 %. The nanoparticles were spherical and their surfaces were rough. The sizes of nanocrystals (Pa-PNC) were less than 200 nm, the loading efficiency could reach 50 %, and the appearances of Pa-PNCs were rod.Conclusion:The Pa-Brij78 could be fabricated into two kinds of drug delivery systemby different methods. And the Pa-Brij78 has the potential to apply in the field of drug delivery.

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