| 赵敏 刘凤岐 马丹 周晋 曲仁海 李竹琴.应用NT-proBNP评价常规药物加心区交感神经阻滞对心衰治疗的有效性[J].现代生物医学进展英文版,2015,15(34):6762-6765. |
| 应用NT-proBNP评价常规药物加心区交感神经阻滞对心衰治疗的有效性 |
| Evaluation Value of NT- proBNP to the Effectiveness of CSNB withConventional Drugs in Patients with Chronic Heart Failure |
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| DOI： |
| 中文关键词: 慢性心力衰竭 N-端脑利钠肽前体 心区交感神经阻滞 |
| 英文关键词: Chronic heart failure N-terminal brain natriuretic peptide Cardiac sympathetic blockade |
| 基金项目:黑龙江省科技厅科学技术研究项目（GC06C41902） |
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| 中文摘要: |
| 目的:利用常规药物加心区交感神经阻滞（CSNB）技术治疗（以下简称治疗）慢性心力衰竭，观察治疗前后患者血浆N- 端脑
利钠肽前体（NT-proBNP）水平变化情况及利用NT-proBNP评价常规药物加CSNB对心衰治疗的有效性。方法：对54 例慢性心衰
患者给予常规药物加CSNB治疗，比较治疗前后血浆NT-proBNP 的水平、左室射血分数（LVEF）、左室舒张末内径（LVEDD）变化
情况，随访6 个月内不良事件（以下简称事件）发生率（包括全因病死率和再入院率之和）。结果：治疗后患者3-8 分钟即感觉呼吸
困难等临床症状体征明显减轻，住院期间患者尿量明显增多，无一例死亡；治疗14日及出院时血浆NT-proBNP 明显下降（出院时
下降比例为61.4%），与治疗前比较其差异有显著统计学意义（P＜0.01）；LVEF升高，与治疗前比较其差异有显著统计学意义（P＜
0.01）；住院14日及出院时LVEDD较入院时缩小。随访6 个月，发生事件12 例（22.2%）。结论：NT-proBNP是评价心衰治疗有效
性的可信指标，常规药物加CSNB治疗心衰的临床疗效明显优于单纯常规药物治疗。 |
| 英文摘要: |
| Objective:To observe of changes plasma N-terminal brain natriuretic peptide (NT-proBNP)level in patients with
chronic heart failure(CHF) undergone cardiacsympathetic blockade(CSNB) treatment with conventional drugs, and evaluate the value of
NT-proBNP in predicting CSNB for the treatment of CHF.Methods:A total of 54 cases of CHF patients undergone CSNB with
conventional drugs were measured Plasma NT-proBNP level, LVEF and LVEDD, Patients were followed up for 6 months, The primary
end point was adverse events incliding all-cause mortality and readmission.Results:The symptoms of dyspnea were reduced at 3-8
minutes after treatment, The urine volume of patients increased significantly, and there was no case of death at hospitalization period.
Plasma NT-proBNP decreased significantly (61.4) at 14 days and Discharged (P < 0.01), LVEF increased than 14 days and Discharged (P
< 0.01) and LVEDD reduced, the event rate following up for 6 months was 22.2.Conclusion:The NT- proBNP level is credible for
evaluation of treatment in CHF. The clinical curative effect of CSNB with conventional drugs is better than conventional drugs for the
treatment in CHF. |
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