| 柴少卿 艾荣 于少飞 王文兰 朱华.支气管哮喘患儿血清25 羟维生素D3水平对病情评估及临床转归的意义[J].现代生物医学进展英文版,2015,15(34):6721-6724. |
| 支气管哮喘患儿血清25 羟维生素D3水平对病情评估及临床转归的意义 |
| Detection of Serum25 Hydroxyl Vitamin D3 in Condition Assessment andClinical Outcome of Children with Bronchial Asthma |
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| DOI： |
| 中文关键词: 哮喘 1,25 羟维生素D 儿童哮喘控制测试 |
| 英文关键词: Asthma 1, 25 hydroxyl vitamin D Childhood asthma control test |
| 基金项目:卫生部医药卫生科技发展研究中心项目（W2013GJ09） |
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| 中文摘要: |
| 目的：探讨支气管哮喘患儿血清25 羟维生素D3[25-(OH)D3］水平对病情严重程度及临床转归的影响。方法：选取144 例
支气管哮喘患儿为研究对象，依据病情严重程度分为轻度间歇组、轻度持续组、中度持续组及重度持续组，选取60 例健康儿童作
为对照组，检测血清25-(OH)D3 水平；在治疗4 周后应用儿童哮喘控制测试评分系统(C-ACT)对患儿哮喘控制情况给予评价，将
所有患儿分为未控制组、部分控制组及完全控制组，比较各组血清25-(OH)D3 水平的差异。结果：对照组、轻度间歇组、轻度持续
组、中度持续组、重度持续组5 组之间血清25-(OH)D3 水平存在显著的统计学差异(P＜0.05)，从对照组到重度持续组血清25-
(OH)D3 水平逐渐降低(P＜0.05)；完全控制组、部分控制组及未控制组三组血清25-(OH)D3 水平亦存在显著的统计学差异(P＜
0.05)，从完全控制组到未控制组血清25-(OH)D3 水平亦呈现逐渐降低趋势(P＜0.05)；血清25-(OH)D3 水平与病情严重程度呈负
相关(rs =-0.489, P＜0.05)，血清25-(OH)D3 水平与C-ACT 评分亦呈负相关(rs =-0.470, P＜0.05)；随着血清25-(OH)D3 水平下降
程度的加重，患儿发生重度持续发作、出现C-ACT 评分＜19 分的风险值(OR)则逐渐增大。结论：血清25-(OH)D3 水平与哮喘患儿
病情严重程度及病情控制情况密切相关，早期血清维生素D 水平对于哮喘患儿病情及近期预后具有一定意义。 |
| 英文摘要: |
| Objective:To study the significance of detection of serum 25 hydroxyl vitamin D3 in condition assessment and
clinical outcome of children with bronchial asthma.Methods:Between April 2013 and February 2013, 144 cases of children with
bronchial asthma in our hospital were chosen as the research object. According to the illness severity, they were divided into mild
intermittent group, mild continued group, moderate continued group and severe continued group. Selected 60 cases of healthy check-up
of normal children as control group, and detected their serum 25- (OH)D3 levels. At 4 weeks after treatment, childhood asthma control
test (C-ACT) was applied for evaluation. Then according to the scoring results, all the children were divided into un-controlled group,
partial-controlled group and complete-controlled group. The serum 25- (OH) D3 levels were compared between the groups.Results:The
serum 25- (OH)D3 level presented statistically significant differences between the control group, mild intermittent group, mild continued
group, moderate continued group and severe continued group (P<0.05). The level reduced gradually from control group to severe group
(P < 0.05). It also presented statistical difference between the un-controlled group, partial-controlled group and complete-controlled group
(P< 0.05), with a trend of gradual reduce from complete controlled group to un-controlled group (P < 0.05). The serum 25-(OH)D3 level
was negatively correlated with disease severity (rs =-0.489, P < 0.05) and C-ACT score (rs=-0.470, P<0.05). The severe continuing attack
and the value at risk (OR) of C-ACT score < 19 points increase gradually along with the aggravating of serum 25-(OH)D3 level reduction
degree.Conclusion:Serum 25- (OH)D3 level is closely related to the asthmatic severity and disease control. Early serumvitamin D level
has a certain significance for recent prognosis of children with asthma disease. |
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