| 王君 李霞 原迪 王越 李潇.GnRH-a 对子宫内膜异位症患者血清CA125、EMAB及RANTES的影响[J].现代生物医学进展英文版,2015,15(34):6686-6688. |
| GnRH-a 对子宫内膜异位症患者血清CA125、EMAB及RANTES的影响 |
| Effect of GnRH-a on the CA125, EMAB and RANTES in Patients withEndometriosis |
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| DOI： |
| 中文关键词: 促性腺激素释放激素激动剂 子宫内膜异位症 CA125 抗子宫内膜抗体 RANTES |
| 英文关键词: GnRH-a Endometriosis CA125 EMAB RANTES |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 目的：探讨促性腺激素释放激素激动剂（GnRH-a）对子宫内膜异位症患者血清CA125、EMAB及RANTES的影响。方法：选
取我院收治的子宫内膜异位症患者92 例，根据治疗方法不同分为两组，对照组予以常规治疗，治疗组在对照组基础上加用醋酸
亮丙瑞林微球注射治疗。检测两组患者治疗前后血清CA125、EMAB 及RANTES水平。结果：与治疗前相比，两组患者治疗后
CA125、RANTES 明显降低，EMAB 转阴率明显升高，差异有统计学意义（P＜0.05）；与对照组相比，治疗组患者治疗后CA125、
RANTES水平降低，EMAB 转阴率升高，差异有统计学意义（P＜0.05）；治疗组不良反应发生率低于对照组，差异有统计学意义
（P＜0.05）。结论：GnRH-a 能够降低子宫内膜异位症患者血清CA125、RANTES 及EMAB水平，提高机体免疫功能，安全性较高，
对临床具有指导意义。 |
| 英文摘要: |
| Objective:To investigate the effect of GnRH-a on the levels of CA125, EMAB and RANTES in patients with
endometriosis.Methods:92 patients with endometriosis who were treated in our hospital were selected and according to the different
treatment methods, the patients were divided into the control group and the treatment group. The patients in the control group were
treated with the conventional method, while the patients in the treatment group were treated with leuprorelin acetate microspheres. Then
the levels of RANTES, EMAB and CA125 in the serum of patients in the two groups were detected and compared before and after the
treatment.Results:Compared with before treatment, the levels of CA125 and RANTES decreased, and the negative rate of EMAB
increased after the treatment (P<0.05). Compared with the control group, the levels of CA125 and RANTES in the treatment group
decreased, and the negative rate of EMAB increased after the treatment (P<0.05). The incidence of adverse reactions in the treatment
group was lower than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:GnRH-a can reduce
the levels of EMAB, RANTES and CA125 in the serum of patients with endometriosis, and improve the immune function and safety of
patients, which has the significance for clinical treatment. |
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