| 王兴洲 张日东 石敏 张红 高鹏霞.2 型糖尿病大血管病变患者血清趋化素与hs-CRP的相关性[J].现代生物医学进展英文版,2015,15(33):6525-6527. |
| 2 型糖尿病大血管病变患者血清趋化素与hs-CRP的相关性 |
| Type 2 Diabetes Complicated with Macroangiopathy: Correlation betweenSerumChemerin and hs-CRP Level |
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| DOI： |
| 中文关键词: 2型糖尿病 大血管病变 趋化素 超敏C反应蛋白 |
| 英文关键词: Type 2 diabetes mellitus Macroangiopathy Chemerin High-sensitivity C-reactive protein |
| 基金项目:江苏省淮安市科技支撑计划社会发展项目（HASZ2013031） |
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| 中文摘要: |
| 目的：观察2 型糖尿病（type2 diabetes mellitus, T2DM）大血管病变患者血清趋化素（chemerin）和超敏C- 反应蛋白（high-sensitivity
C-reactive protein, hs-CRP）的水平及其相关性。方法：选择我院2013 年4 月至2015 年4 月收治的T2DM患者60 例，根据
患者血管病变情况分为糖尿病大血管病变组和单纯糖尿病组，每组30 例。另选择同期来我院体检的健康志愿者30 例作为对照
组。检测三组血清chemerin和hs-CRP 水平并分析。结果：糖尿病大血管病变组和单纯糖尿病组血清chemerin和hs-CRP 水平均
显著高于对照组（P<0.05）；糖尿病大血管病变组血清chemerin 和hs-CRP 水平均显著高于单纯糖尿病组（P<0.05）；糖尿病大血管
病变组血清chemerin 与hs-CRP 呈正相关（r=0.451，P<0.05）。结论：T2DM大血管病变患者血清chemerin 水平显著增高，血清
chemerin 水平与炎症指标hs-CRP存在正相关，chemerin 可能通过介导炎症在T2DM大血管病变过程中发挥作用。 |
| 英文摘要: |
| Objective:To explore the level of serum chemerin and high-sensitivity C-reactive protein (hs-CRP) and their correlation
in type2 diabetes mellitus (T2DM) patients complicated with macroangiopathy.Methods:A total of 60 patients with T2DM, who
were treated in Huai'an First Hospital Affiliated to Nanjing Medical University from April 2013 to April 2015, were selected and divided
into diabetic macroangiopathy group(n=30) and simple diabetes group(n=30) according to their vascular lesions.Another 30 healthy volunteers,
receiving health examination during the same period, were chosen as control group. The serumlevels of chemerin and hs-CRP of
the three groups were detected and analyzed.Results:The serumchemerin and hs-CRP levels of the diabetic macroangiopathy group and
simple diabetes group were all significantly higher than that of the control group (P<0.05). The serum chemerin and hs-CRP levels of the
diabetic macroangiopathy group were higher than that of the simple diabetes group (P<0.05). The levels of chemerin and hs-CRP in diabetic
macroangiopathy group showed a positive correlation (r=0.451, P<0.05).Conclusion:The serumchemerin level of T2DMpatients
complicated with macroangiopathy is significantly elevated and positively correlated with inflammatory factor hs-CRP, and chemerin
may play a role in the pathophysiology of diabetic macroangiopathy by mediating inflammation. |
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