| 崔彦杰 张峰波 黄国虹 黄睿 郝立君 胡金伟 丁剑冰.多发性骨髓瘤骨病患者血清中IL-6 和TRACP-5b 表达的临床意义[J].现代生物医学进展英文版,2015,15(32):6290-6292. |
| 多发性骨髓瘤骨病患者血清中IL-6 和TRACP-5b 表达的临床意义 |
| Clinical Significance of IL-6 and TRACP-5b Expression in Patients with MBD |
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| DOI： |
| 中文关键词: 多发性骨髓瘤 白介素-6 抗酒石酸盐酸性磷酸酶 |
| 英文关键词: Multiple myeloma Interleukin-6 TRACP-5b |
| 基金项目:新疆教育厅自治区级重点学科建设项目（XYDXK50780328） |
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| 中文摘要: |
| 目的：探讨患者血清中白介素-6（Interleukin-6，IL-6）、抗酒石酸盐酸性磷酸酶（Tartrate-resistant acid phosphatase，TRACP-5b）
的水平在多发性骨髓瘤骨病(Multiple myeloma bone disease，MBD) 发病中的作用及其临床意义。方法：采用双抗体夹心酶联免疫
吸附试验法（Enzyme linked immunosorbent assay，ELISA）检测43 例MBD 患者组及22 例MM患者组（无骨损害）及40 例健康对
照组血清中的IL-6、TRACP-5b 的水平，并对检测结果进行统计学分析。结果：MBD 患者组血清IL-6、TRACP-5b (27.93±
7.45，21.33± 5.66)水平较MM 患者组（无骨损害）（13.58± 4.85，7.23± 2.86）、健康对照组（5.65± 2.57，6.76± 2.65）明显升高，差异
有统计学意义（P<0.01）；Ⅲ 期MM 患者血清IL-6、TRACP-5b 水平（31.92± 7.84，24.2± 7.86）明显高于I 期(11.58± 4.85，7.13±
2.86)、Ⅱ期（22.45± 6.51，14.65± 6.76）MM患者，差异有统计学意义（P<0.01）；MBD患者血清IL-6 与血清TRACP-5b 水平呈正相
关（r=0.915，P<0.01）。结论：检测MM患者血清IL-6、TRACP-5b 水平可以作为MBD的辅助诊断指标，血清IL-6、TRACP-5b 可能
参与了MBD的发生和发展。 |
| 英文摘要: |
| Objective:To study the function and clinical significance of interleukin-6 (IL-6) and tartrate-resistant acid phosphatase
(TRACP-5b) expression in multiple myeloma bone disease(MBD).Methods:Enzyme linked immunosorbent assay(ELISA) were used to
detedcte serum level of IL-6 and TRACP-5b in 43 MBD patients, 22 MM patients (No bone damage ) and 40 healthy controls, then
statistical analysis was conducted.Results:The IL-6 and TRACP-5b serum levels of MBD patients groups (27.93± 7.45, 21.33± 5.66)
were much higher compare to MMpatients(No bone damage) (13.58± 4.85, 7.23± 2.86) and healthy control groups(5.65± 2.57, 6.76±
2.65). The serumlevels of IL-6 and TRACP-5b in stage Ⅲ MBD patients(31.92± 7.84, 24.2± 7.86)were much higher than those in stage
I (11.58± 4.85, 7.13± 2.86) and Ⅱ (22.45± 6.51,14.65± 6.76); Both the differences were statistical significance (P<0.01). The serum
level IL-6 was positively correlated to the level of TRACP-5b (r=0.915，P<0.01).Conclusion:Detection serum levle of IL-6 and
TRACP-5b could be helpful to diagnoze MBD; and IL-6 and TRACP-5b might take part in the process of occurrence and development of
MBD. |
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