| 庄海容 刘平 陈圣文 翁时萍 胡学政.年龄相关性黄斑变性患者黄斑区脉络膜新生血管特征分析[J].现代生物医学进展英文版,2015,15(32):6286-6289. |
| 年龄相关性黄斑变性患者黄斑区脉络膜新生血管特征分析 |
| Characteristics Analysis of Age-related Macular Degeneration with MacularChoroidal Neovascularization |
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| DOI： |
| 中文关键词: 年龄相关性黄斑变性 荧光素眼底血管造影 相干光断层扫描 脉络膜新生血管 |
| 英文关键词: Age-related macular degeneration Fluorescent fundus angiography Optical coherent tomography Choroidal
neovascularization |
| 基金项目:国家自然科学基金项目(30973275) |
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| 中文摘要: |
| 目的：探讨年龄相关性黄斑变性黄斑区脉络膜新生血管(CNV)的特征。方法：对41 例(41 只眼)年龄相关性黄斑变性患者
CNV 进行荧光素眼底血管造影(FFA)和相干光断层扫描(OCT)检查，并对两种不同的图像检查结果进行对比分析。结果：FFA 发
现典型CNV29 眼，FFA 早期黄斑区可见边界清晰的高荧光区，FFA 晚期荧光扩大并增强；隐匿型CNV10 眼，FFA早期可见边界
欠清的强荧光，FFA 晚期持续为荧光素渗漏或染色，边界多不清晰。OCT 发现典型CNV33 眼，显示CNV 多位于视网膜神经上皮
层下，呈边界清晰的纺锤形或圆形强反射，隐匿型CNV8 眼，表现为视网膜色素上皮层平面不规则增强紊乱的反射信号。两种检
查对黄斑区CNV 的检出率对比差异无统计学意义(P>0.05)。结论：结合FFA 和OCT的图像特征对年龄相关性黄斑变性黄斑区脉
络膜新生血管形态学改变进行对比分析，有助于明确病变的性质，为临床诊疗提供帮助。 |
| 英文摘要: |
| Objective:To explore the characteristics of macular choroidal neovascularization (CNV) of age-related macular
degeneration (AMD) patients.Methods:41 AMD patients (41 eyes) diagnosed CNV was detected by fluorescent fundus angiography
(FFA) and optical coherent tomography (OCT). The image inspection results was compared and analyzed.Results:29 eyes with typical
CNV were found by FFA which showed high fluorescence area with clearly boundary was detected at early stage in macula and was
expanded and enhanced at late stage; 10 eyes with occult CNV were found by FFA which showed high fluorescence area with less clear
boundary at early stage in macula, and the fluorescein leaked or stained with usually unclear boundary at late stage. OCT found 33 eyes
were typical CNV which was located in subretinal neuroepithelium with clear boundary spindle or round strong reflection, 8 eyes were
occult CNV, which showed irregular enhanced reflection signal at retinal pigment epithelium. There was no significant difference (P>
0.05) between two methods to detect macular CNV.Conclusion:FFA and OCT morphological characteristics of AMD patients are
closely related, combined FFA and OCT image features of AMD patients with macular CNV can help contribute to clarify the nature of
the lesion, which can offer help for clinical diagnosis and treatment. |
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