| 张娴 沙明磊 姚玉婷 戴嘉 倪秀石.腹型肥胖对急性冠脉综合征患者冠状动脉病变严重程度的影响[J].现代生物医学进展英文版,2015,15(32):6255-6258. |
| 腹型肥胖对急性冠脉综合征患者冠状动脉病变严重程度的影响 |
| Influence of Abdominal Obesity on Severity of Coronary Artery Lesion inPatients with Acute Coronary Syndromes |
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| DOI： |
| 中文关键词: 腹型肥胖 急性冠脉综合征 冠状动脉病变 严重程度 |
| 英文关键词: Abdominal obesity Acute coronary syndromes Coronary artery lesion Severity |
| 基金项目: |
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| 中文摘要: |
| 目的：研究腹型肥胖对急性冠脉综合征(ACS)患者冠状动脉病变严重程度的影响。方法：选择2012 年4 月至2013 年4 月在
我院接受治疗的ACS患者120 例，根据腰围身高比(RWH) 将患者分为无腹型肥胖者60 例（对照组，RWH<0.5）及腹型肥胖者60
例（观察组，RWH＜0.5）。测量所有患者的基本参数，计算RWH，利用冠脉造影判断冠脉病变的支数和程度，根据Gensini 评分法
对冠脉造影结果进行评价，分析冠脉病变范围、Gensini积分和RWH 的相关性。结果：观察组的收缩压（SBP）、空腹血糖（FPG）、总
胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）及Gensini 积分水平均显著高于对照组，差异均有统计学意义（均P＜0.05）。
观察组的高密度脂蛋白（HDL-C）水平显著低于对照组，差异有统计学意义（P＜0.05）。双支病变的RWH 及Gensini积分水平显著
高于单支病变，三支病变的RWH 及Gensini 积分水平显著高于单支病变及双支病变，差异均有统计学意义（均P＜0.05）。根据
Spearman 法分析相关性可知，冠脉病变范围、Gensini 积分和RWH 均呈正相关（r=0.635，0.739；P=0.000，0.000）。结论：ACS患者
RWH 水平增高与冠脉病变的严重程度关系密切，有效控制腹型肥胖对于降低心血管类疾病发病率以及降低冠脉病变的程度具
有重要意义。 |
| 英文摘要: |
| Objective:To explore the influence of abdominal obesity on the severity of coronary artery lesion in patients with
acute coronary syndromes (ACS).Methods:A total of 120 patients with ACS, who were treated in First People's Affiliated Hospital of
Shanghai Jiaotong University fromApril 2012 to April 2013, according to the ratio of waist to height (RWH), were divided into 60 cases
of non-abdominal obesity(as control group, RWH<0.5), and 60 cases of abdominal obesity(as observation group, RWH<0.5). Tthe basic
data of the two groups were measured, and the RWH was calculated. The severity and the numbers of coronary artery lesion were judged
by using coronary angiography. The coronary angiography results were evaluated by Gensini score. The correlation between the range of
coronary artery lesion, Gensini score and RWH were analyzed.Results:The levels of SBP, FBG, TC, TG, LDL-C and Gensini score in
the observation group were significantly higher than those in the control group, the differences were statistically significant (P<0.05), but
the HDL-C in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.
05). Gensini score and RWH in the patients with two arteries lesions were significantly higher than those in the patients with single artery
lesion, and Gensini score and RWH in the patients with three arteries lesions were higher than those in the patients with single artery and
two arteries lesions, the differences were statistically significant (P<0.05). Spearman correlation analysis showed that the range of
coronary artery lesion and Gensini score were positively correlated with RWH (r=0.635, 0.739; P=0.000, 0.000).Conclusion:The high
level of RWH in the patients with ACS is closely correlated with the severity of coronary artery lesion,therefore, so effectively controlling
the abdominal obesity has an important significance in reducing the morbidity of cardiovascular disease and alleviating the severity of
coronary artery lesion. |
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