| 何鹏 常瑞 张浩 梁求真 马拓 马俊.骨碎补对骨性关节炎患者骨关节滑膜组织中miR-27a、miR-146a表达的影响[J].现代生物医学进展英文版,2015,15(31):6153-6155. |
| 骨碎补对骨性关节炎患者骨关节滑膜组织中miR-27a、miR-146a表达的影响 |
| Effect of Rhizoma Drynariae on the Expressions of miR-27a and miR-146a inthe Joint Synovial Tissues of Patients with Osteoarthritis |
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| DOI： |
| 中文关键词: 骨碎补 骨性关节炎 miR-27a miR-146a |
| 英文关键词: Rhizoma drynariae Osteoarthritis miR-27a miR-146a |
| 基金项目:陕西省科学技术研究发展计划项目(2011kjxx33) |
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| 中文摘要: |
| 目的：探讨骨碎补对骨性关节炎患者骨关节滑膜组织中miR-27a、miR-146a 表达的影响。方法：选取我院收治的骨性关节炎
患者46 例，随机分为两组，每组各23 例。对照组予抗骨增生治疗，实验组在对照组基础上加以骨碎补治疗。观察和比较两组患者
的临床疗效、炎性因子水平的变化以及骨关节滑膜组织中miR-27a、miR-146a的表达情况。结果：①治疗后，两组患者的临床症状
均有所改善，且实验组疗效高于对照组，差异有统计学意义(P＜0.05)。②治疗后，两组患者的IL-1beta、PGE2 水平均较治疗前显著降
低，且实验组降低较对照组更明显，差异均有统计学意义(P＜0.05)。③治疗后，两组患者的骨关节滑膜组织中的miR-27a、
miR-146a 表达均降低，且与对照组比较，实验组较低，差异有统计学意义(P＜0.05)。结论：骨碎补能够降低骨性关节炎患者骨关节
滑膜组织中miR-27a、miR-146a 的表达，降低IL-1beta、PGE2 的水平，提高临床疗效。 |
| 英文摘要: |
| Objective:To investigate the effect of rhizoma drynariae joint synovial tissue on the expressions of miR-27a and
miR-146a in patients with osteoarthritis.Methods:46 patients with osteoarthritis who were treated in our hospital were randomly divided
into two groups, with 23 patients in each group. The patients in the control group were treated with anti bone hyperplasia, while the patients
in the experimental group were treated with rhizoma drynariae besides the regular treatment. Then the clinical effects and the
changes of miR-27a and miR-146a in the of two groups were observed and compared.Results:① After treatment, the clinical symptoms
in the two groups improved, and the experimental group was better than that of the control group, and the difference was statistically significant
(P<0.05). ②After treatment, the inflammatory factor expression in the two groups reduced, and the experimental group was lower
than that of the control group (P<0.05). ③After treatment, the expressions of miR-27a and miR-146a dcreased, and the experimental
group was lower than those of the control group (P< 0.05).Conclusion:Rhizoma drynariae could affect the expressions of miR-27a and
miR-146a, reduce the productions of inflammatory cytokines, and improve the clinical effect. |
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