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目的：观察不同剂量辛伐他汀治疗老年高血脂患者疗效与安全性。方法：将纳入研究的80 例老年高血脂患者随机分为高剂量组和低剂量组，各40 例。高剂量组给予辛伐他汀剂40 mg/ 日，低剂量组给予20 mg/日。治疗2个月后观察疗效、血脂水平变化情况，并统计两组不良反应的发生情况。结果：高剂量组总有效率95%显著高于低剂量组的80%（P<0.05）；治疗后，两组TG、TC、 LDL-C、HDL-C 水平均有改善，与本组治疗前比较均有显著性差异（P 均<0.05），且高剂量组上述指标改善明显优于低剂量组（P 均<0.05）；治疗期间两组不良反应发生率无统计学意义（P>0.05）。结论：辛伐他汀高剂量（40 mg/日）治疗老年高血脂的疗效优于低剂量（20 mg/ 日），且不增加不良反应发生的风险。

英文摘要:

Objective:To observe the efficacy and safety of different doses of simvastatin in the treatment of elderly patients with hyperlipemia.Methods:A total of 80 elderly patients with hyperlipemia were randomly divided into high dose group (n=40) and low dose group (n=40). The high dose group was treated with 40 mg/d simvastatin, while the low dose group, 20 mg/d simvastatin. After 2 months of treatment, the efficacy and blood lipid levels of the two groups were observed, and the incidence of adverse reactions in the two groups was analyzed.Results:The total effective rate(95%) in the high dose group was significantly higher than that(80%) in the low dose group (P<0.05). Compared with before treatment, the levels of TG, TC, LDL-C, HDL-C in the two groups after treatment were significantly improved( P<0.05), and the above indexes in the high dose group were significantly better than those in the low dose group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The efficacy of high dose of simvastatin(40mg/d) is better than that of low dose of simvastatin(20 mg/d) in the treatment of elderly patients with hyperlipemia, which does not increase the incidence of adverse reactions.

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