| 陆莎 祖超 陈召 王艳 冯征 卢强 张天翼 李小飞.肺鳞癌、腺癌组织中miRNA-210 表达对预后影响的初步研究[J].现代生物医学进展英文版,2015,15(31):6095-6100. |
| 肺鳞癌、腺癌组织中miRNA-210 表达对预后影响的初步研究 |
| Prognostic Impact of miRNA-210 for Squamous Cell Carcinoma andAdenocarcinoma of the Lung |
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| DOI： |
| 中文关键词: miRNA-210 肺鳞癌腺癌 预后因素 |
| 英文关键词: miRNA-210 Squamous cell carcinoma and adenocarcinoma of the lung Prognostic factor |
| 基金项目:国家自然科学基金项目(81172224) |
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| 中文摘要: |
| 目的：探讨肺鳞癌腺癌组织中miRNA-210 表达水平对预后的影响。方法：选取我院2004 年至2007 年接受手术治疗的肺鳞
癌腺癌患者80 例，采用定量RT-PCR测定的方法miRNA-210 在肺癌组织中的表达，并分析其与患者临床病理特点及组织类型之
间的关系。结果：定量RT-PCR 测定结果显示，miRNA-210 与肺鳞癌腺癌患者的无病生存期和总生存期负相关(DFS，P=0.001；OS，
P=0.004)。miRNA-210 与腺癌患者淋巴结转移（P=0.018）、晚期疾病（P=0.003）及较差的预后（P=0.002）显著相关。多因素Cox 分析
显示miRNA-210 是腺癌患者无病生存期的独立预后因子（P< 0.001）。结论：肺腺癌病人肿瘤组织重miRNA-210 可能为预后的生
物标志物。 |
| 英文摘要: |
| Objective:To investigate the prognostic value of MicroRNA-210 (miRNA-210) expression in patients with squamous
cell carcinoma and adenocarcinoma of the lung.Methods:We examined the miRNA-210 expression of samples of 80 patients, who
underwent surgicalresection at our hospital from 2004 to 2007, by using quantitative RT-PCR. The relationship between
miRNA-210expression and clinicopathological factors as well as histological subtype was statistically analyzed.Results:miRNA-210
expression showed an inverse correlation with disease-free and overall survival in patients with squamous cell carcinoma and
adenocarcinoma of the lung by using quantitative RT-PCR (DFS, P=0.001; OS, P=0.004). Significant correlations were found between
miRNA-210 expression and lymph node metastasis (P=0.018), late disease stages (P=0.003), and poor prognosis in patients with
adenocarcinoma (P=0.002). Multivariate Cox analysis indicated that miRNA-210 expression was an independent prognostic factor for
disease-free survival in patients with adenocarcinoma (P＜0.001).Conclusion:We showed that miRNA-210 may be a prognostic
biomarker for patients with squamous cell carcinoma and adenocarcinoma of the lung, especially for those with lung adenocarcinoma. |
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