| 李雪 郝铭 李宏增 郭俊 张慜 汪杰 李川 李柱一.出血性卒中后抑郁患者认知功能与生活质量的研究[J].现代生物医学进展英文版,2015,15(31):6057-6059. |
| 出血性卒中后抑郁患者认知功能与生活质量的研究 |
| Study on Cognitive Function and Quality of Life of Patients with Depressionafter Hemorrhagic Stroke* |
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| DOI： |
| 中文关键词: 卒中后抑郁 认知功能 生活质量 |
| 英文关键词: Post-Stroke Depression Cognitive function Quality of life |
| 基金项目:国家自然科学基金项目（81301022） |
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| 中文摘要: |
| 目的：探讨不同时期出血性脑卒中后抑郁（Post-Stroke Depression，PSD）患者认知功能和生活质量的特征。方法：采用前瞻性
队列研究，对57 例PSD患者和91 例非PSD（None PSD，NPSD）患者在基线期、6 周和12 周后分别进行临床神经功能缺损程度评
分量表（China Stroke Scale，CSS）、汉密尔顿抑郁量表（Hamilton Depression Scale，HAMD）、蒙特利尔认知评估量表（Montreal Cognitive
Assessment，MoCA）和Barthel指数（Barthel Index，BI）的评估。结果：基线期PSD 和NPSD 患者MoCA 总分[分别为（11.6±
2.9）分、（11.2± 3.1）分]和BI总分[分别为（45.6± 8.3）分、（46.2± 7.2）分]，差异无统计学意义（P>0.05）；治疗6 周和12 周后PSD 组
MoCA 总分[分别为（13.4± 2.3）分、（18.2± 3.2）分]和BI 总分[分别为（63.8± 6.5）分、（77.2± 4.1）分]均低于NPSD 组[分别为
（15.8± 2.8）分、（22.6± 2.4）分；（72.2± 7.5）分、（85.8± 5.6）分]，差异有统计学意义（P<0.000）。结论：在卒中的康复后期，PSD患者
较NPSD患者认知功能障碍损害更严重，生活质量更差。推测认知功能是PSD 患者长期预后的独立预测因素，可为PSD 患者康
复策略的制定提供帮助。 |
| 英文摘要: |
| Objective:To explore the characteristics of the cognitive function and quality of life in patients with depression after
hemorrhagic stroke (Post-Stroke Depression, PSD) in different periods.Methods:Prospective cohort study of 57 PSD patients and 91
NPSD patients was designed and the data collection of China Stroke Scale (CSS), Hamilton Depression Scale (HAMD), Montreal Cognitive
Assessment (MoCA) and Barthel Index (BI) occurred during the intervention period at baseline, 6 weeks and 12weeks.Results:The
difference of the MoCA scores and BI scores between PSD patient and NPSD patient at baseline was not statistically significant (11.6±
2.9 vs 11.2± 3.1, P>0.05; 45.6± 8.3 vs 46.2± 7.2, P>0.05 respectively). While the Moca scores and BI scores of PSD patient after 6
weeks and 12 weeks after treatment were significantly lower than NPSD patient (13.4± 2.3 vs 15.8± 2.8, P<0.000; 18.2± 3.2 vs 22.6±
2.4, P<0.000; 63.8± 6.5 vs 72.2± 7.5, P<0.000; 77.2± 4.1 vs 85.8± 5.6, P<0.000).Conclusion:The cognitive function was speculated
as an independent predictor factor of long-termprognosis of PSD patients, which could help to develop PSD rehabilitation strategies. |
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