陈钧 杜莉 王佩 魏虹 韩祖成.环境光导致昼夜节律紊乱对睡眠的影响[J].现代生物医学进展英文版,2015,15(31):6046-6049. |
环境光导致昼夜节律紊乱对睡眠的影响 |
The Effects of Circadian Disruption by Environmental Light on Sleep |
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DOI: |
中文关键词: 昼夜节律 睡眠觉醒 非快速动眼睡眠 快速动眼睡眠 |
英文关键词: Circadian Sleep-wake Non-rapid eye movement sleep (NREM) Rapid eye movement sleep (REM) |
基金项目:国家自然科学基金项目(81402055) |
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中文摘要: |
目的:研究通过环境光扰乱正常昼夜节律对睡眠的影响。方法:使用小鼠昼夜节律模型(20小时一个循环,10小时见光,10
小时避光),利用小鼠睡眠生物解析系统,记录脑电波和肌电波,分析睡眠觉醒量、不同时间睡眠觉醒波delta 功率和睡眠时相转换
等参数。结果:昼夜节律干扰后导致昼夜觉醒差异、非快速眼动睡眠差异(NREM),和快速眼动睡眠(REM)差异消失(P>0.05),昼
夜节律干扰后增加了觉醒和NREM睡眠之间的转换次数(P<0.05),昼夜节律紊乱的光照时相在开始时没有delta 功率减弱征象
(P>0.05)。结论:昼夜节律模型不会导致典型的睡眠剥夺,但是会对睡眠时间和质量会产生影响。本研究一步证实昼夜节律对睡眠
调节有着重要的作用。 |
英文摘要: |
Objective:To study the effects of circadian disruption by environmental light on sleep.Methods:Disrupting the circadian
clock by altered light-dark cycles (a shortened 20 h day, 10 h light, 10 h dark;LD10:10), we used mouse sleeping analysis system to
record electroencephalogram and electromyogram, to analyze sleeping and awaking time in a day, delta power of sleeping and awaking
waves in different time,and times of sleeping and awaking switchover.Results:Environmental circadian disruption by light caused loss
of normal day-night differences in wake, non-rapid eye movement sleep (NREM), and rapid eye movement sleep (REM)(P > 0.05) between
light and dark phases. Circadian disruption increased the number of transitions between wake and NREM(P<0.05). Environmental
circadian disruption by light abolished the normally observed decrease in delta power at the onset of the light phase(P>0.05).Conclusion:Our results demonstrate that this model of circadian disruption did not lead to marked sleep deprivation, but instead affected the timing
and quality of sleep. |
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