| 赵云龙 曲彦隆△ 王强 苗青 李鹏伟.肌腱再生相关转录因子研究进展[J].现代生物医学进展英文版,2015,15(30):5986-5988. |
| 肌腱再生相关转录因子研究进展 |
| Research Progress of Transcription Factors in Tendon Regeneration |
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| DOI： |
| 中文关键词: 肌腱转录因子 Scleraxis Mohawk Sox9 Egr1/2 肌腱再生 |
| 英文关键词: Tendon transcription factors Scleraxis Mohawk Sox9 Egr1/2 Tendon regeneration |
| 基金项目:黑龙江省自然科学基金项目( D201112) |
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| 中文摘要: |
| 肌腱作为骨骼和肌肉的连接往往容易受到损伤，目前对肌腱基本生物学有限的了解妨碍了肌腱修复技术的发展。最近，一
系列肌腱生长相关因子被发现，其中Scleraxis(Scx)和Mohawk(Mkx)已被确定为肌腱生长和分化中的关键转录因子，Sox9 和
EGR1 / 2也被报道参与肌腱的生长。然而，目前研究尚未明确这些转录因子的生物学功能及其分子机制。本文就上述转录因子的
分布与功能，及转录因子相关分子进行综述，为肌腱的修复提供生物学基础并探讨肌腱损伤治疗的未来发展方向。 |
| 英文摘要: |
| Tendons that connect muscles to bone are considered to be the targets of sports injuries. The currently unsatisfactory
state of tendon repair is largely attributable to the limited understanding of basic tendon biology. A number of tendon lineage-related
transcription factors have recently been discovered and proved to provide clues for the better understanding of the development of tendon.
Scleraxis and Mohawk have been identified as critical transcription factors in tendon's development and differentiation. Other
transcription factors, such as Sox9 and Egr1/2 also have been reported to be involved in tendon's development. However, the molecular
mechanisms and the application of those transcription factors have not been clearly proved. This article reviews the distribution and
function of the transcription factors and factors related to them to provide a biological basis, as well as to discuss the future directions of
development for the treatment of tendon repairment. |
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