| 宋燕 李晓云 陈曦 于丽倩 黄睿.预防性应用抗生素对糖皮质激素治疗老年ITP并发感染的影响[J].现代生物医学进展英文版,2015,15(30):5954-5956. |
| 预防性应用抗生素对糖皮质激素治疗老年ITP并发感染的影响 |
| Effect of Preventative Application of Antibiotics on the Incidence of Infectionin Elderly Patients with Idiopathic Thrombocytopenic Purpura Treatedby Glucocorticoid |
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| DOI： |
| 中文关键词: 特发性血小板减少性紫癜 糖皮质激素 老年 感染 |
| 英文关键词: Idiopathic thrombocytopenic purpura(ITP) Glucocorticoids Elderly Infection |
| 基金项目:黑龙江省教育厅科技研究项目(12541530) |
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| 中文摘要: |
| 目的：探讨预防性应用抗生素对糖皮质激素治疗老年特发性血小板减少性紫癜并发感染的影响。方法：将哈尔滨医科大学附
属第二医院血液科2012 年3 月~2015 年3 月的收治的72 例老年特发性血小板减少性紫癜患者随机分为两组，自应用糖皮质激
素第一天开始观察15 天，观察组自应用糖皮质激素开始即使用抗生素，对照组不常规应用抗生素，以出现感染症状即开始应用
抗生素，同时定为观察终止。比较两组患者感染发生率的差异。结果：观察组感染发生率为38.89%，对照组为69.44%，较观察组显
著升高，差异有统计学意义(P＜0.05)。两组患者感染发生部分的分布情况比较无统计学差异(P>0.05)，以呼吸系统感染发生率最
高，其次是尿路感染。结论：预防性的使用抗生素可以降低糖皮质激素治疗老年特发性血小板减少性紫癜患者过程中感染的发生
率。 |
| 英文摘要: |
| Objective:To explore the effect of preventative application of antibiotics on the incidence of infection in elderly
patients with idiopathic thrombocytopenic purpura treated by glucocorticoid.Methods:72 elderly patients with idiopathic
thrombocytopenic purpura admitted in the Department of Hematology of Second Affiliated Hospital of Harbin Medical University from
March 2012 to March 2015 were randomly divided into two groups. the observation group was treated by antibiotics since the use of
glucocorticoids, while the control group was treated by antibiotics when the signs of infection started. The incidence rate of infection was
observed and compared between two groups.Results:The infection rate of observation group was 38.89%, which was 69.44% in the
control group and significantly higher than that in the observation group (P<0.05). No statistical difference was found in the distribution
infections part between two groups (P>0.05), with the highest incidence of respiratory system infection, followed by urinary tract
infections.Conclusion:Prophylactic use of antibiotics could reduce the infection rate during glucocorticoid treatment of senile idiopathic
thrombocytopenic purpura patients. |
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