| 杨爱武 吕宏升 张江灵 陈少谊 林志敏 罗丽云 梁仁佩.晚期胃肠癌患者化疗后血红蛋白水平与临床疗效的相关性分析[J].现代生物医学进展英文版,2015,15(30):5942-5944. |
| 晚期胃肠癌患者化疗后血红蛋白水平与临床疗效的相关性分析 |
| Correlation between Hemoglobin Level and Clinical Efficacy in Patients withAdvanced Gastric Cancer after Chemotherapy |
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| DOI： |
| 中文关键词: 胃肠癌 化疗 血红蛋白 临床疗效 |
| 英文关键词: Gastric cancer Chemotherapy Hemoglobin Clinical efficacy |
| 基金项目: |
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| 中文摘要: |
| 目的：本研究通过回顾性分析晚期胃肠癌患者化疗后血红蛋白（Hb）水平与其临床疗效的关系，为临床治疗提供依据。方法：
选择2009 年1 月~2014 年12 月我院收治的晚期胃肠癌患者共85 例，采用回顾性调查方法，对患者进行1~5 年的随访，分别对
患者化疗前后贫血发生情况、Hb 水平与临床疗效的关系、Hb 水平与患者平均生存时间的关系进行分析。结果：化疗后患者发生贫
血的比例（78.82%）明显高于化疗前（48.24%），差异有统计学意义（P<0.05）；PR 组和SD 组患者化疗前后Hb值的差异无统计学意
义（P>0.05）；化疗前PD组患者Hb 值显著高于化疗后，差异有统计学意义（P<0.05）；Hb 水平越高，患者的平均生存时间越长，Hb
的水平和患者的生存时间呈正相关。结论：晚期胃肠癌患者化疗后贫血发生率增加，化疗后Hb 水平的变化与患者的预后和生存
时间均存在相关关系，对患者进行常规治疗的同时采取相应措施纠正患者贫血症状，有利于改善晚期胃肠癌患者的预后，延长患
者的生存时间。 |
| 英文摘要: |
| Objective:To provide the reference for clinical therapy by retrospectively analysing the correlation of hemoglobin(Hb)
level and clinical efficacy in patients with advanced gastric cancer (AGC) after chemotherapy.Methods:A total of 85 patients with
advanced gastric cancers, who were treated in 180th Hospital of PLA from January 2009 to December 2014, were selected and followed
up for 1-5 years by retrospective survey method.analyzed.The incidence of anemia before and after chemotherapy and the correlation
between Hb level and clinical efficacy and average survival time of the patients.Results:Incidence of anemia (78.82%) after
chemotherapy was significantly higher than that (48.24%) before chemotherapy,the difference was statistically significant(P<0.05). There
was no significant difference in Hb levels before and after chemotherapy between partial response group and stable disease group(P>0.
05);while the Hb level of progressive disease group before chemotherapy was significantly higher than after chemotherapy (P<0.05). The
higher Hb level,the longer average survival time,so the Hb level was positively correlated with survival time of patients.Conclusion:The
incidence of anemia of patients with advanced gastric cancer after chemotherapy increase,so the corresponding measures should be taken
to correct the anemia symptoms of patients when the routine treatment is given to the patients with AGC,which can improve the
prognosis and prolong the survival time of the patients with AGC. |
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