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目的：观察不同剂量戊酸雌二醇治疗宫腔镜术后宫腔粘连的临床效果。方法：选取2013 年6 月-2015 年3 月在我院接受宫腔镜手术且术后出现宫腔粘连的患者80 例，根据用药剂量不同，将所选患者分为小剂量组和大剂量组，每组40 例。小剂量组患者给予戊酸雌二醇3 mg，大剂量组患者给予戊酸雌二醇9 mg 治疗。观察并比较两组患者的临床疗效、月经恢复情况及不良反应发生率。结果：大剂量戊酸雌二醇治疗宫腔粘连的临床疗效显著优于小剂量组，差异具有统计学意义（P＜ 0.05）。大剂量戊酸雌二醇治疗宫腔粘连，患者术后的月经恢复率高于小剂量组，差异具有统计学意义（P＜0.05）。两组不良反应的发生率比较，差异无统计学意义（P＞0.05）。结论：9 mg戊酸雌二醇应用于宫腔镜术后具有较好的效果，能显著降低宫腔粘连发生率。

英文摘要:

Objective:To observe the clinical effect of estradiol valerate with different doses on the treatment of hysteroscopy intrauterine adhesions.Methods:80 cases with intrauterine adhesions who were received the hysteroscopic surgery in our hospital from June 2013 to March 2015 were selected, and according to the different doses, the selected patients were divided into the small dose group and the large dose group, with 40 cases in each group. The patients in the small dose group were treated by estradiol valerate with 3 mg, while the patients in the large dose group were treated by estradiol valerate with 9 mg. The incidence of menstrual cycle were observed and compared two groups of patients with clinical curative effect, the recovery and adverse reaction.Results:The clinical efficacy in the large dose group was significantly better than that of the small dose group, and the difference was statistically significant (P<0.05). The menstrual recovery rate of patients in the large dose group was higher than that of the small dose group, and the difference was statistically significant (P<0.05). There was no statistically significant difference about the incidence of adverse reactions in the two groups (P>0.05).Conclusion:It is better for the patients with intrauterine adhesions by the treatment of 9 mg estradiol valerate, which is worthy of clinical application.

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