| Objective:To investigate the relationship of TGF-beta1, MMP-9, TIMP-1, TNF-alpha, IL-6, IL-10 with paroxysmal atrial
fibrillation(AF) or persistent AF.Methods:The patients was divided into three groups, including 45 paroxysmal AF patients, 30 persistent
AF patients and a control group of 32 paroxysmal suprawentricular tachycardia orWPWpatients who underwent catheter ablation, Serum
samples were respectively taken from left atrium of these patients and , the pre-ablation plasma concentrations of TGF-beta1, MMP-9,
TIMP-1, TNF-alpha, IL-6, IL-10 were evaluated by ELISA. The left atrial diameter (LAD) was detected by echocardiography.Results:Paroxysmal AF group compared with control group, the level of LAD, TGF-茁1, TNF-alpha was increased (P < 0.05), the level of IL - 10 and
TIMP - 1 was lower (P < 0.05), and MMP - 9 had no statistical difference（P>0.05). Persistent AF group compared with control group, the
level of TGF-beta1 had no statistical difference（P>0.05), the level of MMP - 9, TNF-alpha, IL - 6 was higher (P < 0.05), and IL - 10 and TIMP -
1 was lower (P < 0.05). Comparison between paroxysmal AF group and persistent AF group, the levels of TGF-beta1 in paroxysmal AF
group was higher, LAD and the level of MMP - 9 was lower than that of persistent AF group (P < 0.05).Conclusion:Patients with
paroxysmal AF already have structural remodeling, left atrial dilated, and the serum changes of structural remodeling are given priority to
elevated TGF-beta1, while the serumchanges of structural remodeling in persistent AF are given priority to elevated MMP - 9 and IL - 6. |
