| 牛海艳 郑艺菲 王娟玲 蒋洁 蓝永洪.不同临床病理特征的乳腺非特殊型浸润性癌分子亚型分析[J].现代生物医学进展英文版,2015,15(30):5846-5849. |
| 不同临床病理特征的乳腺非特殊型浸润性癌分子亚型分析 |
| Distribution Analysis of Molecular Subtypes in 309 Cases of Non-specificInvasive Breast Cancer with Different Clinicopathological Features |
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| DOI： |
| 中文关键词: 乳腺癌 分子分型 临床病理特点 |
| 英文关键词: Breast cancer Molecular subtype Clinicopathological feature |
| 基金项目:海南医学院科研培育基金项目（HY2013-12）；海南省自然科学基金项目（812194，814301） |
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| 中文摘要: |
| 目的：探讨不同临床病理特征的乳腺非特殊型浸润性癌的分子亚型分布特点。方法：回顾性分析309 例乳腺非特殊型浸润性
癌患者的临床资料，根据患者年龄、绝经情况、组织学分级和淋巴结转移情况分组，每组再根据免疫组化雌激素受体(ER)、孕激素
受体(PR)、人类表皮生长因子受体2(HER-2)结果分为4 种不同的分子亚型，分析各组中不同分子亚型的分布特点。结果：309 例乳
腺非特殊型浸润性癌中Lumina A型为137 例(44.3%)，Lumina B型为64 例(20.7%)，HER-2/neu 型为63 例(20.4%)，basal cell-like
型为45 例(14.6%)。不同年龄段、绝经与否、不同组织学分级和淋巴结转移情况患者的分子亚型差异均具有统计学意义(P<0.05)。
结论：非特殊型浸润性癌的分子亚型以Luminal A型为主，其中异型性高，转移广泛的basal cell-like 型的年龄分布呈现年轻化趋
势。 |
| 英文摘要: |
| Objective:To explore the distribution characteristics of molecular subtypes in 309 cases of non-special invasive breast
cancer with different clinicopathological features.Methods:In retrospective analysis 309 cases of non-special invasive breast cancer
were grouped by age, menopausal status, histopathologic grading and lymph nodes metastasis. In each group molecular subtypes were
defined by immunohistochemical markers including estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth
factor receptor2 (HER2), and the ratio of molecular subtypes were analyzed by clinicopathological features.Results:Among 309 cases,
Luminal A cases were the majority, 137 cases (44.3%), Luminal B was the second largest group, 64 cases (20.7%), HER-2/neu and basal
cell-like were two smallest groups, 63 cases (20.4%) and 45 cases (14.6%) respectively. There were statistic significance in distribution of
molecular subtypes among different age, menopausal status, histopathologic grading and lymph nodes metastasis (P<0.05).Conclusion:Luminal A is the majority in non-special invasive breast cancer, and basal cell-like patients with high atypia and wide metastasis are
getting younger. |
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