| 刘新宇 苗宇 杨春晓 马煦 王晓坤.多巴胺对吗啡成瘾大鼠海马区痛觉调制的研究进展[J].现代生物医学进展英文版,2015,15(29):5776-5778. |
| 多巴胺对吗啡成瘾大鼠海马区痛觉调制的研究进展 |
| The Research Progress of Dopamine on Pain Modulation in Hippocampal ofMorphine Addiction Rats |
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| DOI： |
| 中文关键词: 多巴胺 海马 吗啡 成瘾 痛觉调制 |
| 英文关键词: Dopamine Hippocampus Morphine Addiction Pain modulation |
| 基金项目:国家自然科学基金项目（30240058） |
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| 中文摘要: |
| 当今社会日益增长的吗啡等阿片类药物的非法滥用已经严重威胁到人类的健康。然而，迄今为止尚没有找到能够较为有效
的防治阿片成瘾的方法。目前研究已知，阿片成瘾的形成所涉及的脑区及核团包括中脑腹侧被盖区(VTA)、伏隔核(NAc)、海马等，
其成瘾涉及的神经递质系统包括多巴胺、5-羟色胺等。本文将就多巴胺及海马在痛觉调制及药物成瘾过程中的作用进行综述，为
吗啡的成瘾与戒断的进一研究及治疗提供线索。 |
| 英文摘要: |
| In today's society growing illegal abuse of morphine and other opioids have a serious threat to human health. However,
so far there is no find a more effective method of prevention and treatment of opioid addiction. Known to the present study, the formation
of the brain regions and opioid addiction nuclei including the midbrain ventral tegmental area (VTA), the nucleus accumbens (NAc), hippocampus,
etc., its addiction involved in neurotransmitter system includes dopamine, serotonin and so on. In this article, we will discuss
the function of dopamine and hippocampus in pain modulation and in the process of drug addiction, provide a clues for a research and
tredatment of morphine addiction and withdrawal. |
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