| 陆明海 周波 张青梅 张国印 毛达勇 汤银娟.OSAS 对冠心病患者的血糖和血脂水平的影响[J].现代生物医学进展英文版,2015,15(29):5702-5704. |
| OSAS 对冠心病患者的血糖和血脂水平的影响 |
| Influence of OSAS on Glucose and SerumLipid Levels in Patients withCoronary Heart Disease |
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| DOI： |
| 中文关键词: 阻塞性睡眠呼吸暂停综合征 冠心病 血糖 血脂 相关性 |
| 英文关键词: OSAS CHD Blood glucose Serumlipid Correlation |
| 基金项目:湖北省卫生厅科研项目（WJ2009108） |
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| 中文摘要: |
| 目的：探讨阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome,OSAS) 对冠心病患者血糖和血脂的影响。方法：纳
入我科住院的明确诊断冠心病患者共168 人，根据呼吸暂停低通气指数(Apnea- hypopnea index，AHI)共分2 组：冠心病组133 例，
冠心病合并OSAS 组45 例(轻度OSAS 组16 例；中度OSAS 组18 例，重度OSAS 组12 例)。对比分析冠心病组和冠心病合并
OSAS 组患者血脂及血糖水平及其相关性。结果：BMI、LDL、HDL 在四组间差异有统计学意义(P<0.05)。冠心病合并OSAS 的
BMI、LDL、HDL明显高于冠心病组，各组间BMI 差异有统计学意义(P<0.05)。FPG、HOMA-I、RHbA1、OX-LDL、AHI 在冠心病组
和冠心病合并轻度OSAS组之间差异无统计学意义(P>0.05)。FPG、HOMA-I、RHbA1、OX-LDL、AHI在OSAS轻、中、重各组间差
异有统计学意义(P<0.05)。冠心病合并OSAS 患者AHI和BMI、LDL、FPG、HOMA-I、OX-LDL呈正相关关系(P<0.05)。结论：OSAS
增加了冠心病患者血脂水平和糖尿病的风险，及机制可能与胰岛素抵抗和OX-LDL水平增高有关。 |
| 英文摘要: |
| Objective:To investigate the influence of obstructive sleep apnea syndrome (OSAS) on glucose and serum lipid in patients
with coronary heart disease.Methods:A total of 168 people diagnosed with coronary heart disease were included in this research.
They were divided into two groups: the first group of 133 cases with coronary heart disease (CHD) and the second group of coronary
heart disease combined with OSAS group of 45 cases (16 cases in mild OSAS group, 18 cases in moderate OSAS group, 12 cases in severe
OSAS group) according to the Apnea hypoventilation index (AHI). The levels of serum lipid and glucose and their relevance were
analyzed and compared between groups.Results:The levels of BMI, LDL and HDL had statistical difference between the four groups.
The levels of BMI, LDL and HDL in CHD with OSAS group were significantly higher than in CHD group (P<0.05). There was no difference
in FPG, HOMA-I, RHbA1, OX-LDL, AHI between CHD with mild OSAS group and CHD group (P >0.05). There was statistically
significant difference in FPG, HOMA-I, RHbA1, OX-LDL, AHI between light, medium and heavy groups (P<0.05). AHI in patients of
CHD combined with OSAS group had positive relationship with BMI, LDL, FPG, HOMA-I and OX-LDL (P<0.05).Conclusion:OSAS
increases the risk of coronary heart disease patients with high serum lipid levels and diabetes, and the mechanism may be related to insulin
resistance and OX-LDL increase. |
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