| 马鸿雁 张英茹 王常松 李恩有 石景辉△.硬膜外阻滞对脂多糖致兔急性肺损伤的影响[J].现代生物医学进展英文版,2015,15(29):5624-5627. |
| 硬膜外阻滞对脂多糖致兔急性肺损伤的影响 |
| Effects of Thoracic Epidural Anesthesia on LPS-induced Acute LungInjury in Rabbits |
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| DOI： |
| 中文关键词: 硬膜外 麻醉 脂多糖 急性肺损伤 |
| 英文关键词: Epidural Anesthesia Lipopolysaccharide Acute lung injury |
| 基金项目:黑龙江省科技攻关计划项目（GC09C409-3）；黑龙江省卫生厅项目(2014-282) |
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| 中文摘要: |
| 目的：观察硬膜外阻滞（TEA）对脂多糖（LPS）致急性肺损伤（ALI）兔肺水肿程度及支气管肺泡灌洗液中炎症细胞数量及炎
症因子的影响。方法：66 只日本大耳白兔，随机分为对照组（A 组）、LPS 致伤组（B 组）、LPS致伤加硬膜外阻滞干预组（C 组）。脂多
糖5 mg/kg 缓慢静脉注射复制兔ALI 模型，T4-5 硬膜外腔头侧置管注射0.5 %利多卡因0.3 mL·kg-1·h-1进行干预，监测动脉血气
分析，测支气管肺泡灌洗液中炎症细胞总数并观察肺水肿的程度，ELISA法检测支气管肺泡灌洗液中白介素-8（IL-8）、肿瘤坏死
因子-alpha（TNF-alpha）水平。结果：B 组和C 组中炎症细胞总数明显多于A组，且B组多于C 组，P＜0.05。C组硬膜外阻滞干预后肺水
肿程度较B 组明显减轻，P＜0.05。支气管肺泡灌洗液中IL-8、TNF-琢水平B 组高于C 组，P＜0.05，差异有统计学意义。结论：胸段
硬膜外阻滞能够减轻脂多糖所导致兔的急性肺损伤的肺部炎症反应。 |
| 英文摘要: |
| Objective:o investigate the protective effects of thoracic epidural anesthesia on LPS-induced acute lung injury in rabbits.Methods:66 Japanese flap-eared white rabbits were randomly divided into 3 groups, control group(group A), LPS-induce ALI group
(group B) and thoracic epidural anesthesia group (group C). ALI models of the rabbits were replicated by intravascular LPS injection(5
mg/kg), and the models were considered to have been induced successfully after PaO2/FiO2<300. Group C received 0.5 % lidocaine 0.3
mL/kg via thoracic epidural catheter. The total number of cells in bronchoalveolar lavage fluid(BALF) were measured. The degree of pulmonary
edema was observed by microscope. The level of IL-8 and TNF-alpha in BALF was measured by ELISA.Results:The total number
of cells in group B and C were significantly higher than Group A, and it was higher in groupB than that of group C. In group C, the degree
of pulmonary edema was lighter than in group B. The level of IL-8，TNF-alpha in BALF was lower in C group than in B group.Conclusion:Thoracic epidural anesthesia has protective effect on LPS-induced ALI. |
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