| 程时德 张涛 沈雄山 晏华军 周颖.长效与常规IFN-alpha治疗慢性病毒性肝炎的临床疗效[J].现代生物医学进展英文版,2015,15(28):5531-5534. |
| 长效与常规IFN-alpha治疗慢性病毒性肝炎的临床疗效 |
| Curative Effect of Long-termand Regular alpha-interferonon the Chronic Viral Hepatitis B* |
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| DOI： |
| 中文关键词: 干扰素 慢性病毒性肝炎 临床疗效 |
| 英文关键词: Interferon Chronic viral hepatitis B Clinical curative effect |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨长效与常规alpha- 干扰素（Interferon alpha, IFN alpha）治疗慢性病毒性乙型肝炎（Chr- onic viral hepatitis B, CVHB）的临床疗
效。方法：回顾性分析2010 年1 月~2012 年1 月我院收治的97 例CVHB 患者，在常规黄芩苷治疗方案的基础上，对照组采用常
规IFN alpha-1b 治疗，观察组采用长效IFN alpha-2a 治疗。观察并比较两组患者治疗前后肝功能及不良反应情况。结果：经过48 周治疗，
两组CVHB患者肝功能较治疗前均有显著改善；观察组患者ALT、AST、HA、LN 及r球蛋白（r-G）均显著低于对照组，差异有统
计学意义（P<0.05）；治疗48 周后，观察组患者HBeAg、HBsAg 及HBV-DNA 转阴率显著高于对照组，差异有统计学意义（P<0.
05）；在治疗期间，观察组腹胀及恶心、纳差、乏力等不良反应发生率显著低于对照组，差异有统计学意义（P<0.05）。结论：长效IFN
alpha-2a 治疗CVHB 较常规IFN alpha-1b 疗法更有效改善患者肝功能、提高乙型肝炎病毒转阴率，不良反应少，值得推广。 |
| 英文摘要: |
| Objective:To explore the effect of long-term and regular alpha-interferon (IFN alpha) on chronic viral hepatitis B (CVHB).Methods:97 patients with CVHB were collected in our hospital from January 2010 to January 2012 which including 48 cases in control
group and 49 cases in observation group. On the basis of baicalin treatment, CVHB patients in control group and observation group were
treated by long-term IFN alpha-1b (sinogen) and regular IFN alpha-1b (An Fulong) respectively for 48 weeks. And the liver function and drug
adverse reactions after 24 and 48 weeks was analyzed and compared between the two groups.Results:After 48 weeks, the liver function
in two groups was significantly improved. But the level of ALT, AST, HA, LN and r-globulin (r-G) in the observation group was
significantly lower than that of the control group (P<0.05). After 48 weeks, the seroinversion rate of HBeAg, HBsAg and HBV-DNA in
observation group was significantly higher than that of the control group with statistically significant difference (P < 0.05); the incidence
of adverse reactions such as abdominal distension nausea, anorexia, fatigue in observation group was significantly lower than that of
control group during the treatment (P<0.05).Conclusion:Compared with regular IFN alpha-1b, the long-term IFN alpha-1b+baicalin can more
effectively improve liver function, increase the seroinversion rate of HBV, and reduce the adverse reaction, which is worthy of clinical
promotion. |
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