| 刘益民 金上博 闫耀生 郭智华 马驰 王林.依泽替米贝对胆囊结石患者血清TNF及IL-1水平影响[J].现代生物医学进展英文版,2015,15(28):5512-5515. |
| 依泽替米贝对胆囊结石患者血清TNF及IL-1水平影响 |
| Effects of Ezetimibe on the Level of TNF and IL-1 of the Gallbladder Tissuesin the Patients with Gallstone |
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| DOI： |
| 中文关键词: 依泽替米贝 胆囊结石 TNF IL-1 |
| 英文关键词: Ezetimibe Gallbladder stones TNF IL-1 |
| 基金项目:高等学校博士学科点专项科研基金项目(20120201120079) |
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| 中文摘要: |
| 目的：探究依泽替米贝对胆囊结石患者血清TNF及IL-1 水平变化的影响。方法：选取2014 年8 月至2015 年2 月我院收治
的胆囊结石患者70 例，采用随机数字表随机分为两组，其中对照组35 例，给予溶石疗法等临床常规治疗；实验组35 例，在与对
照组相同的临床常规溶石治疗基础上加用依泽替米贝进行治疗。治疗结束后，比较两组患者胆囊结石数量、重量的差异以及血清
TNF及IL-1 水平变化。结果：①经治疗后实验组患者胆囊内结石平均数量（6.1± 2.5），明显少于对照组（9.2± 2.7），且差异有统计
学意义（t=2.269，P=0.037<0.05）；②经治疗后实验组患者胆囊内结石平均重量（0.17± 3.31）g 明显少于对照组（0.48± 3.04）g，且差
异有统计学意义（t=2.237，P=0.026<0.05）；③经治疗后实验组患者血清TNF水平为（15.93± 4.78）ng/mg，明显低于对照组（22.13±
5.17）ng/mg，且差异有统计学意义（t=2.501，P=0.036<0.05）；④经治疗后实验组患者血清IL-1 水平（63.41± 8.12）ng/mg 明显低于
对照组（89.60± 7.08）ng/mg，且差异有统计学意义（t=2.439，P=0.029<0.05）；⑤治疗后，实验组患者的治疗有效率明显高于对照组，
且差异具有统计学意义（t=2.321，P=0.034<0.05）。结论：依泽替米贝能有效减少结石数量和体积，缓解胆囊结石患者症状，有较好
的临床疗效，对临床治疗具有指导意义，值得临床应用和推广。 |
| 英文摘要: |
| Objective:To study the effect of ezetimibe on the level of TNF and IL-1 in serum of gallstone patients.Methods:70
patients with cholecystolithiasis from August 2014 to February 2015 in our hospital of patients were randomly divided into two groups,
35 patients in control group who were given the litholytic therapyclinical routine treatment; 35 cases in the experimental group who were
added ezetimibe based on the same clinical conventional dissolution treatment as control group. After the end of treatment, the difference
of quantity and weight of gallbladder stones and the level of serum TNF and IL-1 level was detected and compared between the two
groups.Results:①After treatment, the average number of gallbladder stones in experimental group (6.1± 2.5) was significantly lower
than that of the control group (9.2± 2.7), and the difference was statistically significant(t=2.269, P=0.037<0.05);② After treatment, the
average weight of gallbladder stones in the experimental group (0.17± 3.31) g was less than that of the control group (0.48± 3.04) g, and
the difference was statistically significant (t=2.237, P=0.026<0.05); ③After the treatment, the level of TNF in serum of the experimental
group was (63.41 ± 8.12) ng/mg, significantly lower than that of the control group (89.60 ± 7.08) ng/mg, and the difference was
statistically significant(t=2.501, P=0.036<0.05); ④after the treatment, the level of IL-1 in serumof experimental group was (15.93± 4.78)
ng/mg, significantly lower than that of the control group (22.13± 5.17) ng/mg, and the difference was statistically significant(t=2.439,
P=0.029<0.05); ⑤ after treatment, the curative efficiency of experimental group was obviously higher than that of control group, with
statistically significant difference (t=2.321, P=0.034<0.05).Conclusion:Ezetimibe can effectively reduce the number and volume of
stones, alleviate the symptoms of patients with gallbladder stone, has good clinical efficacy, worthy of clinical application and promotion. |
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