| 熊佳时 何刚 李士英 朱英 蒋建龙 何忠惠 张明.血清CA199、CYFR21-1、CEA、NSE水平与肺癌的相关性研究[J].现代生物医学进展英文版,2015,15(28):5492-5495. |
| 血清CA199、CYFR21-1、CEA、NSE水平与肺癌的相关性研究 |
| Study on the Relation between SerumCA199, CYFR21-1, CEA, NSEand Lung Cancer |
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| DOI： |
| 中文关键词: 肺癌 糖蛋白抗原199 细胞角蛋白19 片段21-1 癌胚抗原 神经元特异性烯醇化酶 |
| 英文关键词: Lung cancer CA199 CYFR21-1 CEA NSE |
| 基金项目: |
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| 中文摘要: |
| 目的：分析血清CA199、CYFR21-1、CEA、NSE 水平检测在肺癌诊断及疗效评估中的临床价值，探讨其与肺癌的相关性。方
法：采用化学发光免疫法检测78 例肺癌患者、50 例肺部良性疾病及50 例健康体检者血清CA199、CYFR21-1、CEA、NSE 水平，比
较治疗前后肺癌患者肿瘤标志物水平的变化。结果：肺癌组血清CA199、CYFR21-1、CEA、NSE 水平较对照组、肺良性疾病组均显
著升高(P<0.05)；Ⅲ-Ⅳ期肺癌患者各肿瘤标志物水平均较Ⅰ-Ⅱ期患者明显升高（P<0.05）；四项联合检测的敏感性为79.5 %，明显
高于CA199、CYFR21-1、CEA、NSE 任一单项肿瘤标志物的敏感性（P<0.05）；随着疗效的下降，血清CA199、CYFR21-1、CEA、NSE
水平逐渐升高（P<0.05）。结论：肺癌患者血清CA199、CYFR21-1、CEA、NSE 水平呈高表达状态，且其表达水平与肺癌病情程度密
切相关，联合检测有助于提高肺癌诊断的敏感度及指导治疗方案选择。 |
| 英文摘要: |
| Objective:To analyze the clinical value of serum CA199, CYFR21-1,CEA,NSE for diagnosis and curative evaluation
in patients with lung cancer, and investigate their correlation with lung cancer.Methods:78 cases of lung cancer, 50 cases of benign
pulmonary disease and 50 cases of healthy controls were performed by chemiluminescence to detect the expression of CA199,
CYFR21-1, CEA, NSE, and the change of these tumor markers before and after treatment were also compared.Results:The level of
serumCA199, CYFR21-1, CEA, NSE in lung cancer were significantly higher than those in control group and benign pulmonary disease.
The level of four tumor markers in the clinical stage of Ⅲ-Ⅳ were higher than those in the clinical stage ofⅠ-Ⅱ(P<0.05). The sensibility
of combined detection of four tumor markers was 79.5 %, which was significantly higher than any of tumor marker alone (P<0.05). The
level of serum CA199, CYFR21-1, CEA, NSE was increased with the decrease of clinical effect (P<0.05).Conclusion:Serum CA199,
CYFR21-1, CEA in patients with lung cancer is over-expressed, and positively related with severity of the disease. Combined detection
can contribute to improve the sensitivity of diagnosis, and guide the selection of treatment methods. |
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