| 冷蕾 袁志刚 张承巍 郭伟岩 郭曦 施立刚 李强.西格列汀治疗对初发2 型糖尿病患者血浆vaspin 水平的影响[J].现代生物医学进展英文版,2015,15(28):5480-5483. |
| 西格列汀治疗对初发2 型糖尿病患者血浆vaspin 水平的影响 |
| Effects of Sitagliptin on Plasma Vaspin Level in Patientswith Recent-onset Type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 丝氨酸蛋白酶抑制物 2 型糖尿病 西格列汀 |
| 英文关键词: Vaspin Type 2 Diabetes mellitus Sitagliptin |
| 基金项目:黑龙江省卫生厅科研课题（2012-021） |
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| 中文摘要: |
| 目的：观察西格列汀治疗对初发2 型糖尿病（T2DM）患者血浆丝氨酸蛋白酶抑制物（vaspin）水平的影响，探讨其与胰岛素抵
抗的关系。方法：60 例初发2 型糖尿病患者使用西格列汀治疗12 周，采用酶联免疫法测定正常人及T2DM患者使用西格列汀治
疗前后的血浆vaspin 水平, 分析血浆vaspin水平与体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA- IR )、胰岛素分泌指
数(HOMA- IS )、空腹血糖（FPG）、餐后2 小时血糖（2hPG）、糖化血红蛋白（HbA1C）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋
白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）等的关系。结果：2 型糖尿病组血浆vaspin 水平高于对照组（P＜ 0.05）；2 型糖
尿病组经西格列汀治疗12 周后BMI、WHR、HbA1c、FPG 、2hPG、TG和HOMA-IR 显著下降（P＜0.05），而HOMA-IS 显著升高
（P＜0.05），同时西格列汀治疗后血浆vaspin 水平也显著降低（P＜0.01），且vaspin 水平的降低与HOMA-IR 的改变呈明显正相
关。胰岛素抵抗指数及体重指数是影响血浆vaspin水平的独立相关因素。结论：西格列汀治疗能有效改善2 型糖尿病患者糖脂代
谢和胰岛素敏感性，降低血浆vaspin 水平。 |
| 英文摘要: |
| Objective:To investigate the effects of sitagliptin on plasma vaspin level in patients with recent-onset type 2 diabetes
mellitus, and to study the relationshipbetween insulin sensitivity and vaspin level.Methods:Sixty patients with recent-onset type 2
diabetes mellitus were treated with sitagliptin for 12 weeks. The level of plasma vaspinwas measured by an ELISA. The relationship of
plasma vaspin level with BMI, WHR, HOMA-IR, HOMA-IS, FPG, 2hPG, HbA1C, TG, TC, HDL-C and LDL-C was analyzed.Results:The fasting plasma vaspin level was higher in type 2 diabetes than that in normal control(P＜0.05). After the treatment with sitagliptin for
12 weeks, BMI, WHR, FPG, 2hPG, HbA1C, TG and HOMA-IR in T2DMpatients were significantly lower(P＜0.05), accompanied with
an increase in HOMA-IS (P＜0.05). After treatment with sitagliptin, the level of vaspin was significantly decreased (P＜0.01), and the
change of vaspin concentrationwas correlated positively with the change of HOMA-IR.Conclusion:In type 2 diabetic patients,
sitagliptin treatment can remarkably improve glucose and lipid metabolism,insulin resistance, as well as decrease the plasma vaspin level. |
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