| 张松 任孔华 陈婷 倪唯益 王瑞东.ROC曲线评价Fib、CRP和NT-pro BNP在慢性房颤
并发早期心衰的诊断价值[J].现代生物医学进展英文版,2015,15(27):5359-5361. |
| ROC曲线评价Fib、CRP和NT-pro BNP在慢性房颤
并发早期心衰的诊断价值 |
| Evaluation of Fib, CRP and NT-pro BNP for Chronic Atrial FibrillationPatients Complicated with Early Heart Failure Using ROC Curve |
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| DOI： |
| 中文关键词: 房颤 心衰 C 反应蛋白 纤维蛋白原 氨基末端B 型钠尿肽前体 |
| 英文关键词: Atrial fibrillation Heart failure CRP Fib NT-pro BNP |
| 基金项目:上海市卫生局科研项目（2009HJ0950） |
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| 中文摘要: |
| 目的：探讨CRP、Fib、NT-pro BNP在早期心衰患者中的诊断价值，并通过ROC曲线方法找到临床诊断界值。方法：对48 例
房颤并发早期心衰患者(A组)，31 例为心房颤动并发重度心衰(B 组)和40 健康对照组(C 组)血清Fib、CRP 和NT-pro BNP水平。
利用ROC 曲线，评价CRP、Fib、NT-pro BNP 房颤并发早期心力衰竭诊断效能。结果：CRP、Fib 和NT-pro BNP 在B 组中水平最
高，C 组水平最低，三组间差异具有统计学意义(P<0.05)。NT-pro BNP 的对心房颤动并发早期心力衰竭患者诊断的灵敏度和特异
度明显高于Fib和CRP。NT-pro BNP 曲线下面积明显高于Fib 和CRP，差异有统计学意义(P>0.05)。结论：Fib、CRP 和NT-pro
BNP在房颤并发可能或早期心衰患者血清中水平升高，联合诊断可以提高并发可能心衰的诊断敏感性，使得临床及早干预。 |
| 英文摘要: |
| Objective:To explore of the diagnostic value of CRP, Fib and NT-pro BNP patients with chronic atrial fibrillation
complicated with early heart failure, and find the clinical cut-off point of them using ROC curve method.Methods:To explore of the diagnostic value of CRP, Fib and NT-pro BNP patients with chronic atrial fibrillation
complicated with early heart failure, and find the clinical cut-off point of them using ROC curve method.Results:The levels of CRP, Fib and NT-pro BNP were highest
in group B, and lowest in group C. There was statistically significant difference between the three groups (P <0.05). The sensitivity
and specificity of NT-pro BNP were significantly higher than those of Fib and CRP for patients with atrial fibrillation and early heart failure.
The NT-pro BNP area under curve was significantly higher than that of Fib and CRP, and its difference was statistically significant
(P >0.05).Conclusion:The levels of Fib, CRP and the NT-pro BNP increased in patients with atrial fibrillation complicated with early
heart failure. Joint diagnosis can improve the diagnostic sensitivity, and help to make clinical early intervention |
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